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Increased serum levels of carbohydrate-deficient transferrin in patients with chronic obstructive pulmonary disease

Nihlén, Ulf LU ; Montnemery, Peter LU ; Lindholm, L H and Löfdahl, Claes-Göran LU (2001) In Scandinavian Journal of Clinical & Laboratory Investigation 61(5). p.341-347
Abstract
OBJECTIVE: The reason that only a minority of smokers develop chronic obstructive pulmonary disease (COPD) is still largely unknown. Glycosylation defects are involved in the pathological mechanisms in cystic fibrosis (CF), where chronic progressive obstructive lung disease dominates the clinical picture. Whether defects of protein glycosylation occur in COPD has not previously been examined. Increase in carbohydrate-deficient transferrin (CDT) in serum seems to function as an indicator of general defects of N-glycosylation. Recently, one study observed high serum CDT concentrations in CF patients. We examined whether subjects with COPD also have increased serum CDT levels. METHOD AND RESULTS: A total of 131 randomly selected individuals,... (More)
OBJECTIVE: The reason that only a minority of smokers develop chronic obstructive pulmonary disease (COPD) is still largely unknown. Glycosylation defects are involved in the pathological mechanisms in cystic fibrosis (CF), where chronic progressive obstructive lung disease dominates the clinical picture. Whether defects of protein glycosylation occur in COPD has not previously been examined. Increase in carbohydrate-deficient transferrin (CDT) in serum seems to function as an indicator of general defects of N-glycosylation. Recently, one study observed high serum CDT concentrations in CF patients. We examined whether subjects with COPD also have increased serum CDT levels. METHOD AND RESULTS: A total of 131 randomly selected individuals, 45-64 years of age, underwent a medical examination, spirometry and blood tests. Serum CDT was determined using high performance liquid chromatography. In subjects diagnosed as having COPD (n = 15), multiple logistic regression analyses demonstrated a significant relationship between the diagnosis of COPD and CDT, even after all efforts were made to take the influence of age and smoking into account (odds ratio 3.16, 95% CI 1.11-8.95). Also, in subjects with COPD there was an inverse partial correlation between forced expiratory volume in 1 s (FEV1) and serum CDT (r = -0.81, p = 0.001). CONCLUSION: These results suggest that protein glycosylation defects occur in COPD and, in addition, might be involved in the pathogenetic mechanisms of the disease. It seems that further investigation of the protein glycosylation in COPD is warranted. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glycosylation, Glycoproteins, Fevi, Fibrosis, Cdt, Cystic, Copd, Smoking
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
61
issue
5
pages
341 - 347
publisher
Informa Healthcare
external identifiers
  • pmid:11569480
  • scopus:0034886115
ISSN
1502-7686
DOI
10.1080/00365510120033
language
English
LU publication?
yes
id
af92c191-a77a-41c5-9175-8dffaf139d6d (old id 1122237)
date added to LUP
2008-07-08 10:17:17
date last changed
2018-01-07 09:22:28
@article{af92c191-a77a-41c5-9175-8dffaf139d6d,
  abstract     = {OBJECTIVE: The reason that only a minority of smokers develop chronic obstructive pulmonary disease (COPD) is still largely unknown. Glycosylation defects are involved in the pathological mechanisms in cystic fibrosis (CF), where chronic progressive obstructive lung disease dominates the clinical picture. Whether defects of protein glycosylation occur in COPD has not previously been examined. Increase in carbohydrate-deficient transferrin (CDT) in serum seems to function as an indicator of general defects of N-glycosylation. Recently, one study observed high serum CDT concentrations in CF patients. We examined whether subjects with COPD also have increased serum CDT levels. METHOD AND RESULTS: A total of 131 randomly selected individuals, 45-64 years of age, underwent a medical examination, spirometry and blood tests. Serum CDT was determined using high performance liquid chromatography. In subjects diagnosed as having COPD (n = 15), multiple logistic regression analyses demonstrated a significant relationship between the diagnosis of COPD and CDT, even after all efforts were made to take the influence of age and smoking into account (odds ratio 3.16, 95% CI 1.11-8.95). Also, in subjects with COPD there was an inverse partial correlation between forced expiratory volume in 1 s (FEV1) and serum CDT (r = -0.81, p = 0.001). CONCLUSION: These results suggest that protein glycosylation defects occur in COPD and, in addition, might be involved in the pathogenetic mechanisms of the disease. It seems that further investigation of the protein glycosylation in COPD is warranted.},
  author       = {Nihlén, Ulf and Montnemery, Peter and Lindholm, L H and Löfdahl, Claes-Göran},
  issn         = {1502-7686},
  keyword      = {Glycosylation,Glycoproteins,Fevi,Fibrosis,Cdt,Cystic,Copd,Smoking},
  language     = {eng},
  number       = {5},
  pages        = {341--347},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Increased serum levels of carbohydrate-deficient transferrin in patients with chronic obstructive pulmonary disease},
  url          = {http://dx.doi.org/10.1080/00365510120033},
  volume       = {61},
  year         = {2001},
}