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Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine

Nilsson, Karin; Gustafson, Lars LU and Hultberg, Björn LU (2001) In International Journal of Geriatric Psychiatry 16(6). p.609-614
Abstract
OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS: Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine... (More)
OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS: Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine levels did not improve clinically. CONCLUSIONS: Plasma homocysteine may be the best marker for detecting treatable cobalamin/folate deficiency in patients with dementia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cobalamin, folate, homocysteine, methylmalonic acid, dementia
in
International Journal of Geriatric Psychiatry
volume
16
issue
6
pages
609 - 614
publisher
John Wiley and Sons Ltd
external identifiers
  • pmid:11424170
  • scopus:0034936213
ISSN
1099-1166
DOI
10.1002/gps.388
language
English
LU publication?
yes
id
732f0977-7097-45ed-b951-9d33204c5fd0 (old id 1122314)
date added to LUP
2008-07-08 10:49:04
date last changed
2018-01-07 06:06:22
@article{732f0977-7097-45ed-b951-9d33204c5fd0,
  abstract     = {OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS: Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine levels did not improve clinically. CONCLUSIONS: Plasma homocysteine may be the best marker for detecting treatable cobalamin/folate deficiency in patients with dementia.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1099-1166},
  keyword      = {cobalamin,folate,homocysteine,methylmalonic acid,dementia},
  language     = {eng},
  number       = {6},
  pages        = {609--614},
  publisher    = {John Wiley and Sons Ltd},
  series       = {International Journal of Geriatric Psychiatry},
  title        = {Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine},
  url          = {http://dx.doi.org/10.1002/gps.388},
  volume       = {16},
  year         = {2001},
}