Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
Bengtsson, Kristina ; Melander, Olle LU
; Orho-Melander, Marju
LU
; Lindblad, Ulf
LU
; Ranstam, Jonas
LU
; Råstam, Lennart
LU
and Groop, Leif
LU
(2001)
In Circulation
104(2).
p.187-190
- Abstract
- BACKGROUND: The Arg389 variant of the beta(1)-adrenergic receptor gene mediates a higher isoproterenol-stimulated adenylate cyclase activity than the Gly389 variant in vitro. We investigated whether the Arg389Gly or the Ser49Gly polymorphism is associated with hypertension in Scandinavians. Methods and Results-- A total of 292 unrelated, nondiabetic, hypertensive patients and 265 unrelated healthy control subjects were included in a case-control association study. From 118 families, 102 nondiabetic sibling pairs without antihypertensive medication who were discordant for the Arg389Gly polymorphism were selected for a sibling study. Allele and genotype frequencies of the Arg389Gly and Ser49Gly polymorphisms were compared between... (More)
- BACKGROUND: The Arg389 variant of the beta(1)-adrenergic receptor gene mediates a higher isoproterenol-stimulated adenylate cyclase activity than the Gly389 variant in vitro. We investigated whether the Arg389Gly or the Ser49Gly polymorphism is associated with hypertension in Scandinavians. Methods and Results-- A total of 292 unrelated, nondiabetic, hypertensive patients and 265 unrelated healthy control subjects were included in a case-control association study. From 118 families, 102 nondiabetic sibling pairs without antihypertensive medication who were discordant for the Arg389Gly polymorphism were selected for a sibling study. Allele and genotype frequencies of the Arg389Gly and Ser49Gly polymorphisms were compared between hypertensive patients and normotensive control subjects. Blood pressure and heart rate were compared between carriers of the different genotypes. In the case-control study, the age- and body mass index-adjusted odds ratio for hypertension in subjects homozygous for the Arg389 allele was 1.9 (95% confidence interval, 1.3 to 2.7; P=0.0005) when compared with carriers of 1 or 2 copies of the Gly389 allele. The genotype-discordant sibling pair analysis revealed that siblings homozygous for the Arg389 allele had significantly higher diastolic blood pressures (79.4+/-9.9 versus 76.0+/-10.1 mm Hg; P=0.003) and higher heart rates (68.3+/-11.0 versus 65.1+/-9.4 bpm; P=0.02) than siblings carrying 1 or 2 copies of the Gly389 allele. The Ser49Gly polymorphism was not associated with hypertension. CONCLUSION: Our data suggest that individuals homozygous for the Arg389 allele of the beta(1)-adrenergic receptor gene are at increased risk to develop hypertension. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122545
- author
- Bengtsson, Kristina
; Melander, Olle
LU
; Orho-Melander, Marju
LU
; Lindblad, Ulf
LU
; Ranstam, Jonas
LU
; Råstam, Lennart
LU
and Groop, Leif
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Circulation
- volume
- 104
- issue
- 2
- pages
- 187 - 190
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:11447084
- ISSN
- 1524-4539
- language
- English
- LU publication?
- yes
- id
- 6e3c7f4e-0b4f-43aa-bb5b-07ab6913e0f6 (old id 1122545)
- alternative location
- http://circ.ahajournals.org/cgi/content/short/104/2/187
- date added to LUP
- 2016-04-01 16:42:29
- date last changed
- 2024-03-13 10:34:46
@article{6e3c7f4e-0b4f-43aa-bb5b-07ab6913e0f6,
abstract = {{BACKGROUND: The Arg389 variant of the beta(1)-adrenergic receptor gene mediates a higher isoproterenol-stimulated adenylate cyclase activity than the Gly389 variant in vitro. We investigated whether the Arg389Gly or the Ser49Gly polymorphism is associated with hypertension in Scandinavians. Methods and Results-- A total of 292 unrelated, nondiabetic, hypertensive patients and 265 unrelated healthy control subjects were included in a case-control association study. From 118 families, 102 nondiabetic sibling pairs without antihypertensive medication who were discordant for the Arg389Gly polymorphism were selected for a sibling study. Allele and genotype frequencies of the Arg389Gly and Ser49Gly polymorphisms were compared between hypertensive patients and normotensive control subjects. Blood pressure and heart rate were compared between carriers of the different genotypes. In the case-control study, the age- and body mass index-adjusted odds ratio for hypertension in subjects homozygous for the Arg389 allele was 1.9 (95% confidence interval, 1.3 to 2.7; P=0.0005) when compared with carriers of 1 or 2 copies of the Gly389 allele. The genotype-discordant sibling pair analysis revealed that siblings homozygous for the Arg389 allele had significantly higher diastolic blood pressures (79.4+/-9.9 versus 76.0+/-10.1 mm Hg; P=0.003) and higher heart rates (68.3+/-11.0 versus 65.1+/-9.4 bpm; P=0.02) than siblings carrying 1 or 2 copies of the Gly389 allele. The Ser49Gly polymorphism was not associated with hypertension. CONCLUSION: Our data suggest that individuals homozygous for the Arg389 allele of the beta(1)-adrenergic receptor gene are at increased risk to develop hypertension.}},
author = {{Bengtsson, Kristina and Melander, Olle and Orho-Melander, Marju and Lindblad, Ulf and Ranstam, Jonas and Råstam, Lennart and Groop, Leif}},
issn = {{1524-4539}},
language = {{eng}},
number = {{2}},
pages = {{187--190}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Circulation}},
title = {{Polymorphism in the beta(1)-adrenergic receptor gene and hypertension}},
url = {{http://circ.ahajournals.org/cgi/content/short/104/2/187}},
volume = {{104}},
year = {{2001}},
}