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Hög tid att pröva hypotermi i behandlingen av slaganfall

Wieloch, Tadeusz LU and Boris-Möller, Fredrik LU (2001) In Läkartidningen 98(18). p.2172-2175
Abstract
There is a revived clinical interest in hypothermia as a neuroprotective intervention in brain ischemia. This originates from the experimental finding that hypothermia of only 3 degrees C-4 degrees C below normal body temperature completely abolishes neuronal damage from an ischemic insult that is lethal in normothermia. The idea that hypothermia protects cells from ischemic damage mainly by lowering metabolic rate is challenged. We propose that detrimental protein-lipid interactions in brain cells, that are activated during and following brain ischemia and that mediate adverse cellular signaling and lead to cell death, are blunted or prevented by mild hypothermia.
Please use this url to cite or link to this publication:
author
organization
alternative title
[High time to test hypothermia in the treatment of stroke]
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
98
issue
18
pages
2172 - 2175
publisher
Swedish Medical Association
external identifiers
  • pmid:11402595
  • scopus:0035795824
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
e5a17457-9d37-4d67-82d3-160e5f8744c1 (old id 1122708)
alternative location
http://ltarkiv.lakartidningen.se/artNo22894
date added to LUP
2008-07-18 14:36:58
date last changed
2018-01-07 09:10:14
@article{e5a17457-9d37-4d67-82d3-160e5f8744c1,
  abstract     = {There is a revived clinical interest in hypothermia as a neuroprotective intervention in brain ischemia. This originates from the experimental finding that hypothermia of only 3 degrees C-4 degrees C below normal body temperature completely abolishes neuronal damage from an ischemic insult that is lethal in normothermia. The idea that hypothermia protects cells from ischemic damage mainly by lowering metabolic rate is challenged. We propose that detrimental protein-lipid interactions in brain cells, that are activated during and following brain ischemia and that mediate adverse cellular signaling and lead to cell death, are blunted or prevented by mild hypothermia.},
  author       = {Wieloch, Tadeusz and Boris-Möller, Fredrik},
  issn         = {0023-7205},
  language     = {swe},
  number       = {18},
  pages        = {2172--2175},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Hög tid att pröva hypotermi i behandlingen av slaganfall},
  volume       = {98},
  year         = {2001},
}