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The diagnosis of bacterial vaginosis and vaginal flora changes

Hellberg, D; Nilsson, S and Mårdh, Per-Anders LU (2001) In Archives of Gynecology and Obstetrics 265(1). p.11-15
Abstract
In a population of 956 women, attending for contraceptive advice, 131 (13.7%) were found to have BV acording to Amsel's criteria. Clue cells were detected in 200 (20.9%) women, a positive amine ('sniff') test in 191 (20.0%), a vaginal pH > or = 4.7 in 243 (25.4%) and a "characteristic" vaginal discharge in 104 (10.9%) women. Sensitivity, specificity, positive and negative predictive values in relation to BV were calculated for each of these four criteria. The detection of clue cells, an increased pH and a positive sniff test showed excellent sensitivity (86-100%) values, but had a less satisfactory positive predictive value (52-68%). Vaginal discharge was found to be a poor predictor of BV. The vaginal flora in women with clue cells,... (More)
In a population of 956 women, attending for contraceptive advice, 131 (13.7%) were found to have BV acording to Amsel's criteria. Clue cells were detected in 200 (20.9%) women, a positive amine ('sniff') test in 191 (20.0%), a vaginal pH > or = 4.7 in 243 (25.4%) and a "characteristic" vaginal discharge in 104 (10.9%) women. Sensitivity, specificity, positive and negative predictive values in relation to BV were calculated for each of these four criteria. The detection of clue cells, an increased pH and a positive sniff test showed excellent sensitivity (86-100%) values, but had a less satisfactory positive predictive value (52-68%). Vaginal discharge was found to be a poor predictor of BV. The vaginal flora in women with clue cells, increased vaginal pH or a positive sniff test was very similar to that of the women with BV, every after excluding concomitant cases of BV and the three respective criteria. Thus, a positive amine test, which is easily performed, strongly suggests BV and a vaginal flora predominated by Gardnerella vaginalis, Mycoplasma hominis, Mobiluncus species and anaerobic species on one hand, and lack of lactobacilli on the other. When there is a clinical suspicion of BV, the sniff test is positive and differential diagnoses are excluded, one can safely treat a woman for bacterial vaginosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bacterial vaginosis, Amine test, Bacteria, Diagnosis
in
Archives of Gynecology and Obstetrics
volume
265
issue
1
pages
11 - 15
publisher
Springer
external identifiers
  • pmid:11327086
  • scopus:0035083024
ISSN
1432-0711
DOI
10.1007/s004040000109
language
English
LU publication?
yes
id
17d0a07c-f55d-4a3a-8461-4d0f6a644653 (old id 1122838)
date added to LUP
2008-06-30 13:26:44
date last changed
2018-05-29 12:16:52
@article{17d0a07c-f55d-4a3a-8461-4d0f6a644653,
  abstract     = {In a population of 956 women, attending for contraceptive advice, 131 (13.7%) were found to have BV acording to Amsel's criteria. Clue cells were detected in 200 (20.9%) women, a positive amine ('sniff') test in 191 (20.0%), a vaginal pH > or = 4.7 in 243 (25.4%) and a "characteristic" vaginal discharge in 104 (10.9%) women. Sensitivity, specificity, positive and negative predictive values in relation to BV were calculated for each of these four criteria. The detection of clue cells, an increased pH and a positive sniff test showed excellent sensitivity (86-100%) values, but had a less satisfactory positive predictive value (52-68%). Vaginal discharge was found to be a poor predictor of BV. The vaginal flora in women with clue cells, increased vaginal pH or a positive sniff test was very similar to that of the women with BV, every after excluding concomitant cases of BV and the three respective criteria. Thus, a positive amine test, which is easily performed, strongly suggests BV and a vaginal flora predominated by Gardnerella vaginalis, Mycoplasma hominis, Mobiluncus species and anaerobic species on one hand, and lack of lactobacilli on the other. When there is a clinical suspicion of BV, the sniff test is positive and differential diagnoses are excluded, one can safely treat a woman for bacterial vaginosis.},
  author       = {Hellberg, D and Nilsson, S and Mårdh, Per-Anders},
  issn         = {1432-0711},
  keyword      = {Bacterial vaginosis,Amine test,Bacteria,Diagnosis},
  language     = {eng},
  number       = {1},
  pages        = {11--15},
  publisher    = {Springer},
  series       = {Archives of Gynecology and Obstetrics},
  title        = {The diagnosis of bacterial vaginosis and vaginal flora changes},
  url          = {http://dx.doi.org/10.1007/s004040000109},
  volume       = {265},
  year         = {2001},
}