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The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology

Paulsson, Kajsa LU ; Säll, Torbjörn LU ; Fioretos, Thoas LU ; Mitelman, Felix LU and Johansson, Bertil LU (2001) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 130(2). p.160-165
Abstract
Although trisomy 8 as a sole change is one of the most common chromosomal abnormalities in myeloid malignancies, it is largely unknown if the incidence of this aberration is influenced by other factors of clinical importance. In the present study, the frequencies of isolated +8 in relation to gender, age, previous treatment with chemo- or radiotherapy, and morphologic subtype were ascertained in published, as well as in our own unpublished, cases of acute myeloid leukemia (AML; n=4,246), myelodysplastic syndromes (MDS; n=1,817), and chronic myeloproliferative disorders (MPD; n=530). The frequencies of +8 were higher in MDS and MPD than in AML (7.5% vs. 5.6%; P<0.01) and varied among the morphologic subtypes of AML and MDS (P<0.001... (More)
Although trisomy 8 as a sole change is one of the most common chromosomal abnormalities in myeloid malignancies, it is largely unknown if the incidence of this aberration is influenced by other factors of clinical importance. In the present study, the frequencies of isolated +8 in relation to gender, age, previous treatment with chemo- or radiotherapy, and morphologic subtype were ascertained in published, as well as in our own unpublished, cases of acute myeloid leukemia (AML; n=4,246), myelodysplastic syndromes (MDS; n=1,817), and chronic myeloproliferative disorders (MPD; n=530). The frequencies of +8 were higher in MDS and MPD than in AML (7.5% vs. 5.6%; P<0.01) and varied among the morphologic subtypes of AML and MDS (P<0.001 and P<0.05, respectively). Trisomy 8 was more common in women than in men with MPD (11% vs. 5.1%; P<0.05). Furthermore, the frequencies of +8 were higher in de novo AML and MDS than in treatment-related cases (6.0% vs. 2.8%; P<0.01 and 8.6% vs. 1.5%; P<0.001, respectively). The incidence also varied significantly with age in AML (P<0.001), being more common in elderly patients. Although the causes for this frequency heterogeneity remain to be elucidated, possible explanations may include different environmental exposures affecting the origin of +8 in AML, MDS, and MPD and the presence of different underlying cryptic primary aberrations. (Less)
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Contribution to journal
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published
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in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
130
issue
2
pages
160 - 165
publisher
Elsevier
external identifiers
  • pmid:11675138
  • scopus:0035886416
ISSN
0165-4608
DOI
language
English
LU publication?
yes
id
0b4040fe-27f1-4650-91a8-5e21e76f58b9 (old id 1123028)
date added to LUP
2008-07-09 10:50:07
date last changed
2018-05-29 11:46:51
@article{0b4040fe-27f1-4650-91a8-5e21e76f58b9,
  abstract     = {Although trisomy 8 as a sole change is one of the most common chromosomal abnormalities in myeloid malignancies, it is largely unknown if the incidence of this aberration is influenced by other factors of clinical importance. In the present study, the frequencies of isolated +8 in relation to gender, age, previous treatment with chemo- or radiotherapy, and morphologic subtype were ascertained in published, as well as in our own unpublished, cases of acute myeloid leukemia (AML; n=4,246), myelodysplastic syndromes (MDS; n=1,817), and chronic myeloproliferative disorders (MPD; n=530). The frequencies of +8 were higher in MDS and MPD than in AML (7.5% vs. 5.6%; P&lt;0.01) and varied among the morphologic subtypes of AML and MDS (P&lt;0.001 and P&lt;0.05, respectively). Trisomy 8 was more common in women than in men with MPD (11% vs. 5.1%; P&lt;0.05). Furthermore, the frequencies of +8 were higher in de novo AML and MDS than in treatment-related cases (6.0% vs. 2.8%; P&lt;0.01 and 8.6% vs. 1.5%; P&lt;0.001, respectively). The incidence also varied significantly with age in AML (P&lt;0.001), being more common in elderly patients. Although the causes for this frequency heterogeneity remain to be elucidated, possible explanations may include different environmental exposures affecting the origin of +8 in AML, MDS, and MPD and the presence of different underlying cryptic primary aberrations.},
  author       = {Paulsson, Kajsa and Säll, Torbjörn and Fioretos, Thoas and Mitelman, Felix and Johansson, Bertil},
  issn         = {0165-4608},
  language     = {eng},
  number       = {2},
  pages        = {160--165},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology},
  url          = {http://dx.doi.org/},
  volume       = {130},
  year         = {2001},
}