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Experimental nerve compression and upregulation of CPON in DRG

Bergmark, Maria; Kanje, Martin LU ; Widerberg, Annika LU and Dahlin, Lars LU (2001) In NeuroReport 12(17). p.3783-3786
Abstract
Expression of C-terminal flanking peptide of neuropeptide Y (CPON) in DRG and cell proliferation (incorporation of BrdU) in sciatic nerve of rats following chronic nerve compression (silicone tubes with different internal diameters) was studied by immunocytochemistry. An increased number of CPON-positive neurons and cells incorporating BrdU was induced on the compressed side, most pronounced when a tight tube was used, while no cells expressed CPON or BrdU in intact nerves. The increase was transient and declined with time. Nerve compression induces transient cell proliferation in the nerve and expression of CPON in nerve cell bodies, but this is of a lesser magnitude than those following nerve transection.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
12
issue
17
pages
3783 - 3786
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:11726794
  • scopus:0035807945
ISSN
1473-558X
language
English
LU publication?
yes
id
13c5a007-724e-4d2a-8450-ccf6168aeaab (old id 1123089)
date added to LUP
2008-06-24 14:35:16
date last changed
2018-01-07 06:20:18
@article{13c5a007-724e-4d2a-8450-ccf6168aeaab,
  abstract     = {Expression of C-terminal flanking peptide of neuropeptide Y (CPON) in DRG and cell proliferation (incorporation of BrdU) in sciatic nerve of rats following chronic nerve compression (silicone tubes with different internal diameters) was studied by immunocytochemistry. An increased number of CPON-positive neurons and cells incorporating BrdU was induced on the compressed side, most pronounced when a tight tube was used, while no cells expressed CPON or BrdU in intact nerves. The increase was transient and declined with time. Nerve compression induces transient cell proliferation in the nerve and expression of CPON in nerve cell bodies, but this is of a lesser magnitude than those following nerve transection.},
  author       = {Bergmark, Maria and Kanje, Martin and Widerberg, Annika and Dahlin, Lars},
  issn         = {1473-558X},
  language     = {eng},
  number       = {17},
  pages        = {3783--3786},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Experimental nerve compression and upregulation of CPON in DRG},
  volume       = {12},
  year         = {2001},
}