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Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment.

Andersson, M; Westin, J E and Cenci Nilsson, Angela LU (2003) In European Journal of Neuroscience 17(3). p.661-666
Abstract
DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)

lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB,... (More)
DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)

lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB, paralleled the time-course of DFosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine. These results suggest that DFosB-like proteins have exceptional in vivo stability. In the dopamine-denervated striatum, these proteins may exert

sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
motor stereotypy, immediate-early genes, drugs of abuse, dyskinesia, Parkinson’s disease
in
European Journal of Neuroscience
volume
17
issue
3
pages
661 - 666
publisher
Wiley-Blackwell
external identifiers
  • wos:000180899600024
  • pmid:12581184
  • scopus:0037330231
ISSN
1460-9568
DOI
language
English
LU publication?
yes
id
60440a5c-f21e-4734-92bc-561832f6484a (old id 112333)
date added to LUP
2007-06-26 09:02:32
date last changed
2018-05-29 09:43:48
@article{60440a5c-f21e-4734-92bc-561832f6484a,
  abstract     = {DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)<br/><br>
lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB, paralleled the time-course of DFosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine. These results suggest that DFosB-like proteins have exceptional in vivo stability. In the dopamine-denervated striatum, these proteins may exert<br/><br>
sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy.},
  author       = {Andersson, M and Westin, J E and Cenci Nilsson, Angela},
  issn         = {1460-9568},
  keyword      = {motor stereotypy,immediate-early genes,drugs of abuse,dyskinesia,Parkinson’s disease},
  language     = {eng},
  number       = {3},
  pages        = {661--666},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neuroscience},
  title        = {Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment.},
  url          = {http://dx.doi.org/},
  volume       = {17},
  year         = {2003},
}