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Reduced frontotemporal perfusion in psychopathic personality

Anckarsäter, Henrik LU ; Hultin, Leif; Tullberg, Mats; Wikkelso, Carsten; Ekholm, Sven and Forsman, Anders (2002) In Psychiatry Research 114(2). p.81-94
Abstract
Several brain-imaging studies have found associations between aberrant functioning in the frontal and temporal lobes and violent offending. We have previously reported decreased frontotemporal perfusion unrelated to psychosis, substance abuse, or current medication in 21 violent offenders. In the present study, we compared the regional cerebral blood flow (rCBF) in a new group of 32 violent offenders to scores on the Psychopathy Checklist-Revised (PCL-R), which rates two aspects of psychopathy: disturbed interpersonal attitudes (Factor 1) and impulsive antisocial behavior (Factor 2). A recently proposed model has split Factor 1 into a new Factor 1 (deceitful interpersonal style), a new Factor 2 (affective unresponsiveness), and a Factor 3,... (More)
Several brain-imaging studies have found associations between aberrant functioning in the frontal and temporal lobes and violent offending. We have previously reported decreased frontotemporal perfusion unrelated to psychosis, substance abuse, or current medication in 21 violent offenders. In the present study, we compared the regional cerebral blood flow (rCBF) in a new group of 32 violent offenders to scores on the Psychopathy Checklist-Revised (PCL-R), which rates two aspects of psychopathy: disturbed interpersonal attitudes (Factor 1) and impulsive antisocial behavior (Factor 2). A recently proposed model has split Factor 1 into a new Factor 1 (deceitful interpersonal style), a new Factor 2 (affective unresponsiveness), and a Factor 3, which approximately corresponds to the old Factor 2. The rCBF was assessed by single-photon emission computed tomography (SPECT) with technetium-99m-d,l-hexamethylpropyleneamine oxime (HMPAO) in regions of interest (ROIs) placed in accordance with fusioned magnetic resonance images (MRI) and SPECT scans. Significant negative correlations were found between interpersonal features of psychopathy (the old and especially the new Factor 1) and the frontal and temporal perfusion. The two most clearly associated ROIs were the head of the caudate nuclei and the hippocampi. These findings in a group of violent offenders living under the same conditions, which reduced the number of state-related confounders, add to the evidence indicating that aberrant frontotemporal activity may be a factor in violent behavior. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Psychopathy Checklist-Revised (PCL-R), Violence, Regional cerebral blood flow (rCBF), HMPAO single-photon emission computed tomography (HMPAO-SPECT)
in
Psychiatry Research
volume
114
issue
2
pages
81 - 94
publisher
Elsevier
external identifiers
  • pmid:12036508
  • scopus:0037097195
ISSN
1872-7123
DOI
10.1016/S0925-4927(02)00006-9
language
English
LU publication?
yes
id
bbee1a3c-6b97-4208-b3f5-027897003fb2 (old id 1124042)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/12036508
http://www.sciencedirect.com/science/article/pii/S0925492702000069
date added to LUP
2013-10-08 15:42:35
date last changed
2017-12-10 03:53:47
@article{bbee1a3c-6b97-4208-b3f5-027897003fb2,
  abstract     = {Several brain-imaging studies have found associations between aberrant functioning in the frontal and temporal lobes and violent offending. We have previously reported decreased frontotemporal perfusion unrelated to psychosis, substance abuse, or current medication in 21 violent offenders. In the present study, we compared the regional cerebral blood flow (rCBF) in a new group of 32 violent offenders to scores on the Psychopathy Checklist-Revised (PCL-R), which rates two aspects of psychopathy: disturbed interpersonal attitudes (Factor 1) and impulsive antisocial behavior (Factor 2). A recently proposed model has split Factor 1 into a new Factor 1 (deceitful interpersonal style), a new Factor 2 (affective unresponsiveness), and a Factor 3, which approximately corresponds to the old Factor 2. The rCBF was assessed by single-photon emission computed tomography (SPECT) with technetium-99m-d,l-hexamethylpropyleneamine oxime (HMPAO) in regions of interest (ROIs) placed in accordance with fusioned magnetic resonance images (MRI) and SPECT scans. Significant negative correlations were found between interpersonal features of psychopathy (the old and especially the new Factor 1) and the frontal and temporal perfusion. The two most clearly associated ROIs were the head of the caudate nuclei and the hippocampi. These findings in a group of violent offenders living under the same conditions, which reduced the number of state-related confounders, add to the evidence indicating that aberrant frontotemporal activity may be a factor in violent behavior.},
  author       = {Anckarsäter, Henrik and Hultin, Leif and Tullberg, Mats and Wikkelso, Carsten and Ekholm, Sven and Forsman, Anders},
  issn         = {1872-7123},
  keyword      = {Psychopathy Checklist-Revised (PCL-R),Violence,Regional cerebral blood flow (rCBF),HMPAO single-photon emission computed tomography (HMPAO-SPECT)},
  language     = {eng},
  number       = {2},
  pages        = {81--94},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Reduced frontotemporal perfusion in psychopathic personality},
  url          = {http://dx.doi.org/10.1016/S0925-4927(02)00006-9},
  volume       = {114},
  year         = {2002},
}