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Interstitial laser hyperthermia of a rat liver adenocarcinoma

Tranberg, Karl-Göran LU ; Myllymäki, L; Möller, P H; Ivarsson, Kjell LU ; Sjögren, Hans Olov LU and Stenram, Unne LU (2002) In Journal of X-Ray Science and Technology 10(3-4). p.177-185
Abstract
The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour... (More)
The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour only, we found that laser thermotherapy reduced take and growth of the untreated tumour in the median lobe indicating that laser thermotherapy may induce immunologic effects. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour as compared to resection. It is suggested that this can be at least partly explained by a laser-induced immunologic effect. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of X-Ray Science and Technology
volume
10
issue
3-4
pages
177 - 185
publisher
IOS Press
ISSN
0895-3996
language
English
LU publication?
yes
id
0002e863-685e-4d96-b259-38232c67b7c4 (old id 1124088)
alternative location
http://iospress.metapress.com/content/v21hjcxkgph0q0vf/
date added to LUP
2008-06-03 14:25:24
date last changed
2016-04-16 05:12:13
@article{0002e863-685e-4d96-b259-38232c67b7c4,
  abstract     = {The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour only, we found that laser thermotherapy reduced take and growth of the untreated tumour in the median lobe indicating that laser thermotherapy may induce immunologic effects. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour as compared to resection. It is suggested that this can be at least partly explained by a laser-induced immunologic effect.},
  author       = {Tranberg, Karl-Göran and Myllymäki, L and Möller, P H and Ivarsson, Kjell and Sjögren, Hans Olov and Stenram, Unne},
  issn         = {0895-3996},
  language     = {eng},
  number       = {3-4},
  pages        = {177--185},
  publisher    = {IOS Press},
  series       = {Journal of X-Ray Science and Technology},
  title        = {Interstitial laser hyperthermia of a rat liver adenocarcinoma},
  volume       = {10},
  year         = {2002},
}