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Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats

Liu, Jian-Jun; Wang, Ji-Yao; Zhang, Chi; Nilsson, Åke LU and Duan, Rui-Dong LU (2002) In Medical Science Monitor 8(2). p.56-60
Abstract
BACKGROUND: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosin staining. RESULTS: Endotoxin increased the BUN and... (More)
BACKGROUND: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosin staining. RESULTS: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-a concentration was also increased by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment significantly attenuates the effects of endotoxin on BUN, creatinine and TNF-a levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. CONCLUSIONS: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Medical Science Monitor
volume
8
issue
2
pages
56 - 60
publisher
Medical Science Monitor
external identifiers
  • pmid:11862160
  • scopus:17644443866
ISSN
1643-3750
language
English
LU publication?
yes
id
97a8c9dd-92d0-4733-b51e-4ab9b76baa28 (old id 1124145)
alternative location
http://www.medscimonit.com/abstracted.php?level=5&icid=420918
date added to LUP
2008-05-26 15:49:21
date last changed
2017-01-01 04:47:58
@article{97a8c9dd-92d0-4733-b51e-4ab9b76baa28,
  abstract     = {BACKGROUND: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosin staining. RESULTS: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-a concentration was also increased by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment significantly attenuates the effects of endotoxin on BUN, creatinine and TNF-a levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. CONCLUSIONS: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC.},
  author       = {Liu, Jian-Jun and Wang, Ji-Yao and Zhang, Chi and Nilsson, Åke and Duan, Rui-Dong},
  issn         = {1643-3750},
  language     = {eng},
  number       = {2},
  pages        = {56--60},
  publisher    = {Medical Science Monitor},
  series       = {Medical Science Monitor},
  title        = {Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats},
  volume       = {8},
  year         = {2002},
}