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Clarithromycin and prednisolone inhibit cytokine production in chronic rhinosinusitis

Wallwork, Ben; Coman, William; Feron, Francois; Mackay-Sim, Alan and Cervin, Anders LU (2002) In Laryngoscope 112(10). p.1827-1830
Abstract
OBJECTIVES: Long-term, low-dose macrolide therapy is effective in the treatment of chronic rhinosinusitis. The mechanism of its anti-inflammatory effect and how this differs from corticosteroids remains unclear. The effect of clarithromycin and prednisolone on interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production by cultured chronic sinusitis nasal mucosa was examined in the study. STUDY DESIGN AND METHODS: Nasal mucosa was obtained from 11 patients with chronic sinusitis. This tissue was cultured for 24 hours in the presence of clarithromycin or prednisolone at a variety of concentrations. Cytokine levels were determined by enzyme-linked immunoassay. RESULTS: Clarithromycin and prednisolone each... (More)
OBJECTIVES: Long-term, low-dose macrolide therapy is effective in the treatment of chronic rhinosinusitis. The mechanism of its anti-inflammatory effect and how this differs from corticosteroids remains unclear. The effect of clarithromycin and prednisolone on interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production by cultured chronic sinusitis nasal mucosa was examined in the study. STUDY DESIGN AND METHODS: Nasal mucosa was obtained from 11 patients with chronic sinusitis. This tissue was cultured for 24 hours in the presence of clarithromycin or prednisolone at a variety of concentrations. Cytokine levels were determined by enzyme-linked immunoassay. RESULTS: Clarithromycin and prednisolone each produced significant reductions in interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production. There was no significant difference between the effects of clarithromycin and prednisolone. CONCLUSION: Macrolide antibiotics are capable of inhibiting pro-inflammatory cytokine production in vitro and are as potent as prednisolone. This mechanism is likely to be at least partly responsible for the clinical efficacy of macrolide antibiotics in chronic rhinosinusitis. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Laryngoscope
volume
112
issue
10
pages
1827 - 1830
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:12368623
  • scopus:0036789432
ISSN
1531-4995
language
English
LU publication?
no
id
be3abdf8-bef1-4f1c-aae4-3cd366046910 (old id 1124204)
date added to LUP
2008-06-03 14:02:45
date last changed
2017-01-01 06:56:43
@article{be3abdf8-bef1-4f1c-aae4-3cd366046910,
  abstract     = {OBJECTIVES: Long-term, low-dose macrolide therapy is effective in the treatment of chronic rhinosinusitis. The mechanism of its anti-inflammatory effect and how this differs from corticosteroids remains unclear. The effect of clarithromycin and prednisolone on interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production by cultured chronic sinusitis nasal mucosa was examined in the study. STUDY DESIGN AND METHODS: Nasal mucosa was obtained from 11 patients with chronic sinusitis. This tissue was cultured for 24 hours in the presence of clarithromycin or prednisolone at a variety of concentrations. Cytokine levels were determined by enzyme-linked immunoassay. RESULTS: Clarithromycin and prednisolone each produced significant reductions in interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production. There was no significant difference between the effects of clarithromycin and prednisolone. CONCLUSION: Macrolide antibiotics are capable of inhibiting pro-inflammatory cytokine production in vitro and are as potent as prednisolone. This mechanism is likely to be at least partly responsible for the clinical efficacy of macrolide antibiotics in chronic rhinosinusitis.},
  author       = {Wallwork, Ben and Coman, William and Feron, Francois and Mackay-Sim, Alan and Cervin, Anders},
  issn         = {1531-4995},
  language     = {eng},
  number       = {10},
  pages        = {1827--1830},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Laryngoscope},
  title        = {Clarithromycin and prednisolone inhibit cytokine production in chronic rhinosinusitis},
  volume       = {112},
  year         = {2002},
}