The serum level of soluble urokinase receptor is elevated in tuberculosis patients and predicts mortality during treatment: a community study from Guinea-Bissau
(2002) In The International Journal of Tuberculosis and Lung Disease 6(8). p.686-692- Abstract
- OBJECTIVE: To investigate whether the serum level of soluble urokinase plasminogen activator receptor (suPAR) carries prognostic information in individuals infected with Mycobacterium tuberculosis. DESIGN: suPAR was measured by ELISA in 262 individuals at the time of enrolment into a cohort based on suspicion of active tuberculosis and in 101 individuals after 8 months of follow-up. RESULTS: The suPAR levels were elevated in patients with active TB compared to TB-negative individuals (P < 0.001). suPAR levels were highest in patients positive for TB on direct microscopy (n = 84, median suPAR 3.17 ng/ml, P < 0.001), followed by patients negative on direct microscopy but culture positive (n = 35, median suPAR 2.41 ng/ml, P = 0.005) and... (More)
- OBJECTIVE: To investigate whether the serum level of soluble urokinase plasminogen activator receptor (suPAR) carries prognostic information in individuals infected with Mycobacterium tuberculosis. DESIGN: suPAR was measured by ELISA in 262 individuals at the time of enrolment into a cohort based on suspicion of active tuberculosis and in 101 individuals after 8 months of follow-up. RESULTS: The suPAR levels were elevated in patients with active TB compared to TB-negative individuals (P < 0.001). suPAR levels were highest in patients positive for TB on direct microscopy (n = 84, median suPAR 3.17 ng/ml, P < 0.001), followed by patients negative on direct microscopy but culture positive (n = 35, median suPAR 2.41 ng/ml, P = 0.005) and by patients diagnosed on clinical grounds (n = 63, median suPAR 2.13 ng/ml, P = 0.06) compared to 64 TB-negative individuals (median suPAR 1.73 ng/ml). During the 8-month treatment period, 23 TB cases died. In a multivariate Cox model controlling for HIV status, age, sex, CD4 count and type of TB diagnosis, the mortality increase per ng suPAR was 1.25 (95%CI 1.12-1.40). After treatment, suPAR levels had decreased to the levels of TB-negative individuals. CONCLUSIONS: suPAR levels are elevated in TB patients and associated with mortality. Furthermore, suPAR may be a potential marker of treatment efficacy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124593
- author
- Eugen-Olsen, J ; Gustafson, Per LU ; Sidenius, N ; Fischer, T K ; Parner, J ; Aaby, P ; Gomes, V F and Lisse, I
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The International Journal of Tuberculosis and Lung Disease
- volume
- 6
- issue
- 8
- pages
- 686 - 692
- publisher
- International Union against Tuberculosis and Lung Disease
- external identifiers
-
- pmid:12150480
- scopus:0035992373
- ISSN
- 1815-7920
- language
- English
- LU publication?
- yes
- id
- 30a5c046-351f-4669-a644-c5c4197a1ec0 (old id 1124593)
- alternative location
- http://www.ingentaconnect.com/content/iuatld/ijtld/2002/00000006/00000008/art00009
- date added to LUP
- 2016-04-01 12:36:34
- date last changed
- 2022-04-21 17:49:32
@article{30a5c046-351f-4669-a644-c5c4197a1ec0,
abstract = {{OBJECTIVE: To investigate whether the serum level of soluble urokinase plasminogen activator receptor (suPAR) carries prognostic information in individuals infected with Mycobacterium tuberculosis. DESIGN: suPAR was measured by ELISA in 262 individuals at the time of enrolment into a cohort based on suspicion of active tuberculosis and in 101 individuals after 8 months of follow-up. RESULTS: The suPAR levels were elevated in patients with active TB compared to TB-negative individuals (P < 0.001). suPAR levels were highest in patients positive for TB on direct microscopy (n = 84, median suPAR 3.17 ng/ml, P < 0.001), followed by patients negative on direct microscopy but culture positive (n = 35, median suPAR 2.41 ng/ml, P = 0.005) and by patients diagnosed on clinical grounds (n = 63, median suPAR 2.13 ng/ml, P = 0.06) compared to 64 TB-negative individuals (median suPAR 1.73 ng/ml). During the 8-month treatment period, 23 TB cases died. In a multivariate Cox model controlling for HIV status, age, sex, CD4 count and type of TB diagnosis, the mortality increase per ng suPAR was 1.25 (95%CI 1.12-1.40). After treatment, suPAR levels had decreased to the levels of TB-negative individuals. CONCLUSIONS: suPAR levels are elevated in TB patients and associated with mortality. Furthermore, suPAR may be a potential marker of treatment efficacy.}},
author = {{Eugen-Olsen, J and Gustafson, Per and Sidenius, N and Fischer, T K and Parner, J and Aaby, P and Gomes, V F and Lisse, I}},
issn = {{1815-7920}},
language = {{eng}},
number = {{8}},
pages = {{686--692}},
publisher = {{International Union against Tuberculosis and Lung Disease}},
series = {{The International Journal of Tuberculosis and Lung Disease}},
title = {{The serum level of soluble urokinase receptor is elevated in tuberculosis patients and predicts mortality during treatment: a community study from Guinea-Bissau}},
url = {{http://www.ingentaconnect.com/content/iuatld/ijtld/2002/00000006/00000008/art00009}},
volume = {{6}},
year = {{2002}},
}