Advanced

Induction of donor-specific tolerance to islet allografts in nonhuman primates.

Gaur, LK; Kennedy, E; Nitta, Y; Nepom, GT; Nelson, KA; Allen, M and Lernmark, Åke LU (2002) In Annals of the New York Academy of Sciences 958. p.194-198
Abstract
Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by... (More)
Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by streptozotocin and required daily doses of insulin to maintain lower blood glucose levels. The diabetic macaques then received islets and stem cells from unrelated and MHC-mismatched donors without any immunosuppression. In our initial analysis, 5 of (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the New York Academy of Sciences
volume
958
pages
194 - 198
publisher
New York Academy of Sciences
external identifiers
  • scopus:0036268624
ISSN
0077-8923
language
English
LU publication?
yes
id
ca7de505-e6b0-4c28-8436-1956f879a0c1 (old id 1124814)
alternative location
http://www.annalsnyas.org/cgi/content/abstract/958/1/194
date added to LUP
2008-05-22 11:51:23
date last changed
2017-01-01 07:15:03
@article{ca7de505-e6b0-4c28-8436-1956f879a0c1,
  abstract     = {Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by streptozotocin and required daily doses of insulin to maintain lower blood glucose levels. The diabetic macaques then received islets and stem cells from unrelated and MHC-mismatched donors without any immunosuppression. In our initial analysis, 5 of},
  author       = {Gaur, LK and Kennedy, E and Nitta, Y and Nepom, GT and Nelson, KA and Allen, M and Lernmark, Åke},
  issn         = {0077-8923},
  language     = {eng},
  pages        = {194--198},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {Induction of donor-specific tolerance to islet allografts in nonhuman primates.},
  volume       = {958},
  year         = {2002},
}