Induction of donor-specific tolerance to islet allografts in nonhuman primates.
Gaur, LK ; Kennedy, E ; Nitta, Y ; Nepom, GT ; Nelson, KA ; Allen, M and Lernmark, Åke LU
(2002)
In Annals of the New York Academy of Sciences
958.
p.194-198
- Abstract
- Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by... (More)
- Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by streptozotocin and required daily doses of insulin to maintain lower blood glucose levels. The diabetic macaques then received islets and stem cells from unrelated and MHC-mismatched donors without any immunosuppression. In our initial analysis, 5 of (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124814
- author
- Gaur, LK
; Kennedy, E
; Nitta, Y
; Nepom, GT
; Nelson, KA
; Allen, M
and Lernmark, Åke
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the New York Academy of Sciences
- volume
- 958
- pages
- 194 - 198
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0036268624
- ISSN
- 0077-8923
- language
- English
- LU publication?
- yes
- id
- ca7de505-e6b0-4c28-8436-1956f879a0c1 (old id 1124814)
- alternative location
- http://www.annalsnyas.org/cgi/content/abstract/958/1/194
- date added to LUP
- 2016-04-01 16:46:55
- date last changed
- 2022-01-28 22:06:49
@article{ca7de505-e6b0-4c28-8436-1956f879a0c1,
abstract = {{Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in which long-term allotolerance would make these treatments routine in a clinical setting. With the specific objective of testing whether peripheral infusions of stem cells or stem cell fractions in conjunction with islet allografting would induce allograft tolerance, we have established a macaque diabetic model. The macaques were rendered diabetic by streptozotocin and required daily doses of insulin to maintain lower blood glucose levels. The diabetic macaques then received islets and stem cells from unrelated and MHC-mismatched donors without any immunosuppression. In our initial analysis, 5 of}},
author = {{Gaur, LK and Kennedy, E and Nitta, Y and Nepom, GT and Nelson, KA and Allen, M and Lernmark, Åke}},
issn = {{0077-8923}},
language = {{eng}},
pages = {{194--198}},
publisher = {{Wiley-Blackwell}},
series = {{Annals of the New York Academy of Sciences}},
title = {{Induction of donor-specific tolerance to islet allografts in nonhuman primates.}},
url = {{http://www.annalsnyas.org/cgi/content/abstract/958/1/194}},
volume = {{958}},
year = {{2002}},
}