Advanced

Investigation of environmental and host-related risk factors for tuberculosis in Africa. II. Investigation of host genetic factors

Bennett, S; Lienhardt, C; Bah-Sow, O; Gustafson, Per LU ; Manneh, K; Del Prete, G; Gomes, V; Newport, M; McAdam, K and Hill, A (2002) In American Journal of Epidemiology 155(11). p.1074-1079
Abstract
In an accompanying paper (Am. J. Epidemiol. 2002;155:1066-73), the authors describe the design of a large multicenter study being carried out in three West African countries for investigation of the roles of environmental and host-related factors in the development of tuberculosis. In this paper, the authors review some evidence that host genetic factors play a role in susceptibility to tuberculosis. They describe the three components of the study that are designed to investigate the effect of host genetic factors on the development of tuberculosis: case-control and family-based association studies of candidate genes and analysis of affected relative pairs to screen the human genome for areas of linkage to the disease. The authors also... (More)
In an accompanying paper (Am. J. Epidemiol. 2002;155:1066-73), the authors describe the design of a large multicenter study being carried out in three West African countries for investigation of the roles of environmental and host-related factors in the development of tuberculosis. In this paper, the authors review some evidence that host genetic factors play a role in susceptibility to tuberculosis. They describe the three components of the study that are designed to investigate the effect of host genetic factors on the development of tuberculosis: case-control and family-based association studies of candidate genes and analysis of affected relative pairs to screen the human genome for areas of linkage to the disease. The authors also address a number of methodological issues that arise, such as the effects of consanguinity, half-siblings, and nonpaternity. Lastly, they review opportunities to assess gene-environment interaction in the framework of the study, in light of current methodological knowledge. Consideration of these issues may be useful in the design of other studies of genetic susceptibility to infectious diseases, particularly those to be carried out in developing countries. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Epidemiology
volume
155
issue
11
pages
1074 - 1079
publisher
Oxford University Press
external identifiers
  • pmid:12034587
  • scopus:0036605694
ISSN
0002-9262
language
English
LU publication?
no
id
a3959e78-020f-4132-b27b-afe1ba08ab1a (old id 1124995)
alternative location
http://aje.oxfordjournals.org/cgi/content/abstract/155/11/1074
date added to LUP
2008-05-19 09:15:20
date last changed
2017-06-18 03:47:15
@article{a3959e78-020f-4132-b27b-afe1ba08ab1a,
  abstract     = {In an accompanying paper (Am. J. Epidemiol. 2002;155:1066-73), the authors describe the design of a large multicenter study being carried out in three West African countries for investigation of the roles of environmental and host-related factors in the development of tuberculosis. In this paper, the authors review some evidence that host genetic factors play a role in susceptibility to tuberculosis. They describe the three components of the study that are designed to investigate the effect of host genetic factors on the development of tuberculosis: case-control and family-based association studies of candidate genes and analysis of affected relative pairs to screen the human genome for areas of linkage to the disease. The authors also address a number of methodological issues that arise, such as the effects of consanguinity, half-siblings, and nonpaternity. Lastly, they review opportunities to assess gene-environment interaction in the framework of the study, in light of current methodological knowledge. Consideration of these issues may be useful in the design of other studies of genetic susceptibility to infectious diseases, particularly those to be carried out in developing countries.},
  author       = {Bennett, S and Lienhardt, C and Bah-Sow, O and Gustafson, Per and Manneh, K and Del Prete, G and Gomes, V and Newport, M and McAdam, K and Hill, A},
  issn         = {0002-9262},
  language     = {eng},
  number       = {11},
  pages        = {1074--1079},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Investigation of environmental and host-related risk factors for tuberculosis in Africa. II. Investigation of host genetic factors},
  volume       = {155},
  year         = {2002},
}