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Investigation of environmental and host-related risk factors for tuberculosis in Africa. I. Methodological aspects of a combined design

Lienhardt, C; Bennett, S; Del Prete, G; Bah-Sow, O; Newport, M; Gustafson, Per LU ; Manneh, K; Gomes, V; Hill, A and McAdam, K (2002) In American Journal of Epidemiology 155(11). p.1066-1073
Abstract
Host-related and environmental factors for tuberculosis have usually been investigated separately using different study designs. Joint investigation of the genetic, immunologic, and environmental factors at play in susceptibility to tuberculosis represents an innovative goal for obtaining a better understanding of the pathogenesis of the disease. In this paper, the authors describe methods being used to investigate these points in a West African study combining several designs. Patients with newly diagnosed smear-positive cases of tuberculosis are recruited. The effect of host-related factors is assessed by comparing each case with a healthy control from the case's household. The role of environmental factors is estimated by comparing... (More)
Host-related and environmental factors for tuberculosis have usually been investigated separately using different study designs. Joint investigation of the genetic, immunologic, and environmental factors at play in susceptibility to tuberculosis represents an innovative goal for obtaining a better understanding of the pathogenesis of the disease. In this paper, the authors describe methods being used to investigate these points in a West African study combining several designs. Patients with newly diagnosed smear-positive cases of tuberculosis are recruited. The effect of host-related factors is assessed by comparing each case with a healthy control from the case's household. The role of environmental factors is estimated by comparing cases with randomly selected community controls. The frequencies of candidate gene variants are compared between cases and community controls, and results are validated through family-based association studies. Members of the households of cases and community controls are being followed prospectively to determine the incidence of "secondary" tuberculosis and to evaluate the influence of geographic and genetic proximity to the index case. This type of design raises important methodological issues that may be useful to consider in studies investigating the natural history of infectious diseases and in attempts to disentangle the effects of environmental and genetic factors in response to infection. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Epidemiology
volume
155
issue
11
pages
1066 - 1073
publisher
Oxford University Press
external identifiers
  • pmid:12034586
  • scopus:0036605693
ISSN
0002-9262
language
English
LU publication?
no
id
9b01ac0f-bfdb-4b4f-b5b3-fe8561129dd4 (old id 1125005)
alternative location
http://aje.oxfordjournals.org/cgi/content/abstract/155/11/1066
date added to LUP
2008-05-26 15:13:25
date last changed
2017-07-23 03:55:59
@article{9b01ac0f-bfdb-4b4f-b5b3-fe8561129dd4,
  abstract     = {Host-related and environmental factors for tuberculosis have usually been investigated separately using different study designs. Joint investigation of the genetic, immunologic, and environmental factors at play in susceptibility to tuberculosis represents an innovative goal for obtaining a better understanding of the pathogenesis of the disease. In this paper, the authors describe methods being used to investigate these points in a West African study combining several designs. Patients with newly diagnosed smear-positive cases of tuberculosis are recruited. The effect of host-related factors is assessed by comparing each case with a healthy control from the case's household. The role of environmental factors is estimated by comparing cases with randomly selected community controls. The frequencies of candidate gene variants are compared between cases and community controls, and results are validated through family-based association studies. Members of the households of cases and community controls are being followed prospectively to determine the incidence of "secondary" tuberculosis and to evaluate the influence of geographic and genetic proximity to the index case. This type of design raises important methodological issues that may be useful to consider in studies investigating the natural history of infectious diseases and in attempts to disentangle the effects of environmental and genetic factors in response to infection.},
  author       = {Lienhardt, C and Bennett, S and Del Prete, G and Bah-Sow, O and Newport, M and Gustafson, Per and Manneh, K and Gomes, V and Hill, A and McAdam, K},
  issn         = {0002-9262},
  language     = {eng},
  number       = {11},
  pages        = {1066--1073},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Investigation of environmental and host-related risk factors for tuberculosis in Africa. I. Methodological aspects of a combined design},
  volume       = {155},
  year         = {2002},
}