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New evidence for an association between the CSF HVA:5-HIAA ratio and psychopathic traits

Anckarsäter, Henrik LU ; Blennow, Kaj LU ; Sjodin, A-K and Forsman, A (2003) In Journal of Neurology, Neurosurgery and Psychiatry 74(7). p.918-921
Abstract
OBJECTIVES: To replicate the relation between the CSF HVA:5-HIAA ratio and psychopathic traits previously reported in a pilot group of 22 perpetrators of violent crimes. METHODS: CSF monoamine metabolite concentrations in another 28 violent and sexual offenders, aged 45 or below, referred to pretrial forensic psychiatric investigation, were compared to features of psychopathy according to the Psychopathy Checklist-Revised (PCL-R). RESULTS: Our previous finding was repeated in the new study group, where the HVA:5-HIAA ratio was strongly associated with psychopathic traits (r = 0.50, p = 0.010), particularly its behavioural aspects (r = 0.523, p = 0.004). In subsamples of individuals from both study groups who had no medication (n = 25) or... (More)
OBJECTIVES: To replicate the relation between the CSF HVA:5-HIAA ratio and psychopathic traits previously reported in a pilot group of 22 perpetrators of violent crimes. METHODS: CSF monoamine metabolite concentrations in another 28 violent and sexual offenders, aged 45 or below, referred to pretrial forensic psychiatric investigation, were compared to features of psychopathy according to the Psychopathy Checklist-Revised (PCL-R). RESULTS: Our previous finding was repeated in the new study group, where the HVA:5-HIAA ratio was strongly associated with psychopathic traits (r = 0.50, p = 0.010), particularly its behavioural aspects (r = 0.523, p = 0.004). In subsamples of individuals from both study groups who had no medication (n = 25) or no current axis I disorder, including a history of mood disorder or substance dependence (n = 21), the HVA:5-HIAA ratio remained strongly associated with all psychopathy factors but most closely with the behavioural features. Retrospective assessments of childhood disruptive symptomatology, such as attention deficit hyperactivity disorder or conduct disorder, analysed in relation to the monoamine metabolites, showed the same association with the HVA:5-HIAA ratio. CONCLUSIONS: Violent and aggressive behavioural traits with childhood onset and adult expression as psychopathic features are associated with changed activity in the brain dopaminergic system, possibly as a result of serotonergic dysregulation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
catecholamine, monoamine, violence, conduct disorder, ADHD, PCL-R
in
Journal of Neurology, Neurosurgery and Psychiatry
volume
74
issue
7
pages
918 - 921
publisher
BMJ Publishing Group
external identifiers
  • pmid:12810780
  • scopus:0038480246
ISSN
1468-330X
DOI
language
English
LU publication?
yes
id
e46643f4-a74f-4003-b97c-bf3fe9ae0f2e (old id 1126669)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/12810780
http://jnnp.bmj.com/content/74/7/918.long
date added to LUP
2013-10-09 15:18:35
date last changed
2018-05-29 10:05:32
@article{e46643f4-a74f-4003-b97c-bf3fe9ae0f2e,
  abstract     = {OBJECTIVES: To replicate the relation between the CSF HVA:5-HIAA ratio and psychopathic traits previously reported in a pilot group of 22 perpetrators of violent crimes. METHODS: CSF monoamine metabolite concentrations in another 28 violent and sexual offenders, aged 45 or below, referred to pretrial forensic psychiatric investigation, were compared to features of psychopathy according to the Psychopathy Checklist-Revised (PCL-R). RESULTS: Our previous finding was repeated in the new study group, where the HVA:5-HIAA ratio was strongly associated with psychopathic traits (r = 0.50, p = 0.010), particularly its behavioural aspects (r = 0.523, p = 0.004). In subsamples of individuals from both study groups who had no medication (n = 25) or no current axis I disorder, including a history of mood disorder or substance dependence (n = 21), the HVA:5-HIAA ratio remained strongly associated with all psychopathy factors but most closely with the behavioural features. Retrospective assessments of childhood disruptive symptomatology, such as attention deficit hyperactivity disorder or conduct disorder, analysed in relation to the monoamine metabolites, showed the same association with the HVA:5-HIAA ratio. CONCLUSIONS: Violent and aggressive behavioural traits with childhood onset and adult expression as psychopathic features are associated with changed activity in the brain dopaminergic system, possibly as a result of serotonergic dysregulation.},
  author       = {Anckarsäter, Henrik and Blennow, Kaj and Sjodin, A-K and Forsman, A},
  issn         = {1468-330X},
  keyword      = {catecholamine,monoamine,violence,conduct disorder,ADHD,PCL-R},
  language     = {eng},
  number       = {7},
  pages        = {918--921},
  publisher    = {BMJ Publishing Group},
  series       = {Journal of Neurology, Neurosurgery and Psychiatry},
  title        = {New evidence for an association between the CSF HVA:5-HIAA ratio and psychopathic traits},
  url          = {http://dx.doi.org/},
  volume       = {74},
  year         = {2003},
}