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Proteolysis of the collagen fibril in osteoarthritis

Poole, A Robin; Nelson, Fred; Dahlberg, Leif LU ; Tchetina, Elena; Kobayashi, Masahiko; Yasuda, Tadashi; Laverty, Sheila; Squires, Ginette; Kojima, Toshihisa and Wu, William, et al. (2003) In Biochemical Society Symposia 70. p.115-123
Abstract
The development of cartilage pathology in osteoarthritis involves excessive damage to the collagen fibrillar network, which appears to be mediated primarily by the chondrocyte-generated cytokines interleukin-1 and tumour necrosis factor alpha and the collagenases matrix metalloproteinase-1 (MMP-1) and MMP-13. The damage to matrix caused by these and other MMPs can result in the production of sufficient degradation products that can themselves elicit further degradation, leading to chondrocyte differentiation and eventually matrix mineralization and cell death. Knowledge of these MMPs, cellular receptors and cytokine pathways, and the ability to selectively antagonize them by selective blockade of function, may provide valuable therapeutic... (More)
The development of cartilage pathology in osteoarthritis involves excessive damage to the collagen fibrillar network, which appears to be mediated primarily by the chondrocyte-generated cytokines interleukin-1 and tumour necrosis factor alpha and the collagenases matrix metalloproteinase-1 (MMP-1) and MMP-13. The damage to matrix caused by these and other MMPs can result in the production of sufficient degradation products that can themselves elicit further degradation, leading to chondrocyte differentiation and eventually matrix mineralization and cell death. Knowledge of these MMPs, cellular receptors and cytokine pathways, and the ability to selectively antagonize them by selective blockade of function, may provide valuable therapeutic opportunities in the treatment of osteoarthritis and other joint diseases involving cartilage resorption, such as rheumatoid arthritis. The ability to detect the products of these degradative events released into body fluids of patients may enable us to monitor disease activity, predict disease progression and determine more rapidly the efficacy of new therapeutic agents. (Less)
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type
Contribution to journal
publication status
published
subject
in
Biochemical Society Symposia
volume
70
pages
115 - 123
publisher
Portland Press
external identifiers
  • pmid:14587287
  • scopus:1542495378
ISSN
0067-8694
language
English
LU publication?
no
id
188b1403-213f-40ac-a8f9-142c2e131001 (old id 1127168)
date added to LUP
2008-06-10 09:00:50
date last changed
2017-10-22 04:49:16
@article{188b1403-213f-40ac-a8f9-142c2e131001,
  abstract     = {The development of cartilage pathology in osteoarthritis involves excessive damage to the collagen fibrillar network, which appears to be mediated primarily by the chondrocyte-generated cytokines interleukin-1 and tumour necrosis factor alpha and the collagenases matrix metalloproteinase-1 (MMP-1) and MMP-13. The damage to matrix caused by these and other MMPs can result in the production of sufficient degradation products that can themselves elicit further degradation, leading to chondrocyte differentiation and eventually matrix mineralization and cell death. Knowledge of these MMPs, cellular receptors and cytokine pathways, and the ability to selectively antagonize them by selective blockade of function, may provide valuable therapeutic opportunities in the treatment of osteoarthritis and other joint diseases involving cartilage resorption, such as rheumatoid arthritis. The ability to detect the products of these degradative events released into body fluids of patients may enable us to monitor disease activity, predict disease progression and determine more rapidly the efficacy of new therapeutic agents.},
  author       = {Poole, A Robin and Nelson, Fred and Dahlberg, Leif and Tchetina, Elena and Kobayashi, Masahiko and Yasuda, Tadashi and Laverty, Sheila and Squires, Ginette and Kojima, Toshihisa and Wu, William and Billinghurst, R Clark},
  issn         = {0067-8694},
  language     = {eng},
  pages        = {115--123},
  publisher    = {Portland Press},
  series       = {Biochemical Society Symposia},
  title        = {Proteolysis of the collagen fibril in osteoarthritis},
  volume       = {70},
  year         = {2003},
}