Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes
(2003) In Journal of Clinical Endocrinology and Metabolism 88(11). p.5090-5098- Abstract
- Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of... (More)
- Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of diabetes, lower body mass index, less glycemic improvement, and persistent insulin requirement. HLA class II genotyping showed that the A-beta- group differed from the A+beta- group in having lower frequencies of two alleles strongly associated with (Less)
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https://lup.lub.lu.se/record/1127391
- author
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 88
- issue
- 11
- pages
- 5090 - 5098
- publisher
- Oxford University Press
- external identifiers
-
- scopus:10744227156
- pmid:14602731
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2003-030180
- language
- English
- LU publication?
- yes
- id
- 3d5a9e09-a8f7-4548-afe4-6752b7e33e8b (old id 1127391)
- date added to LUP
- 2016-04-01 17:01:11
- date last changed
- 2022-03-07 17:59:48
@article{3d5a9e09-a8f7-4548-afe4-6752b7e33e8b, abstract = {{Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of diabetes, lower body mass index, less glycemic improvement, and persistent insulin requirement. HLA class II genotyping showed that the A-beta- group differed from the A+beta- group in having lower frequencies of two alleles strongly associated with}}, author = {{Maldonado, Mario and Hampe, Christiane S and Gaur, Lakshmi K and D'Amico, Susana and Iyer, Dinakar and Hammerle, Lisa P and Bolgiano, Douglas and Rodriguez, Lucille and Rajan, Arun and Lernmark, Åke and Balasubramanyam, Ashok}}, issn = {{1945-7197}}, language = {{eng}}, number = {{11}}, pages = {{5090--5098}}, publisher = {{Oxford University Press}}, series = {{Journal of Clinical Endocrinology and Metabolism}}, title = {{Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes}}, url = {{http://dx.doi.org/10.1210/jc.2003-030180}}, doi = {{10.1210/jc.2003-030180}}, volume = {{88}}, year = {{2003}}, }