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Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Covassin, Laurence; Desjardins, Michel; Soulet, Denis LU ; Charest-Gaudreault, Rene; Audette, Marie and Poulin, Richard (2003) In Bioorganic & Medicinal Chemistry Letters 13(19). p.3267-3271
Abstract
Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioorganic & Medicinal Chemistry Letters
volume
13
issue
19
pages
3267 - 3271
publisher
Elsevier
external identifiers
  • pmid:12951106
  • scopus:0042832967
ISSN
1090-2120
DOI
language
English
LU publication?
no
id
071b5ce6-5ad6-4071-ac26-28492069da2b (old id 1128080)
date added to LUP
2008-06-04 11:10:21
date last changed
2018-05-29 09:39:51
@article{071b5ce6-5ad6-4071-ac26-28492069da2b,
  abstract     = {Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.},
  author       = {Covassin, Laurence and Desjardins, Michel and Soulet, Denis and Charest-Gaudreault, Rene and Audette, Marie and Poulin, Richard},
  issn         = {1090-2120},
  language     = {eng},
  number       = {19},
  pages        = {3267--3271},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry Letters},
  title        = {Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition},
  url          = {http://dx.doi.org/},
  volume       = {13},
  year         = {2003},
}