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Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Covassin, Laurence ; Desjardins, Michel ; Soulet, Denis LU ; Charest-Gaudreault, Rene ; Audette, Marie and Poulin, Richard (2003) In Bioorganic & Medicinal Chemistry Letters 13(19). p.3267-3271
Abstract
Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioorganic & Medicinal Chemistry Letters
volume
13
issue
19
pages
3267 - 3271
publisher
Elsevier
external identifiers
  • pmid:12951106
  • scopus:0042832967
ISSN
0960-894X
DOI
10.1016/S0960-894X(03)00668-1
language
English
LU publication?
no
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
071b5ce6-5ad6-4071-ac26-28492069da2b (old id 1128080)
date added to LUP
2016-04-01 12:14:02
date last changed
2022-01-27 00:49:37
@article{071b5ce6-5ad6-4071-ac26-28492069da2b,
  abstract     = {{Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.}},
  author       = {{Covassin, Laurence and Desjardins, Michel and Soulet, Denis and Charest-Gaudreault, Rene and Audette, Marie and Poulin, Richard}},
  issn         = {{0960-894X}},
  language     = {{eng}},
  number       = {{19}},
  pages        = {{3267--3271}},
  publisher    = {{Elsevier}},
  series       = {{Bioorganic & Medicinal Chemistry Letters}},
  title        = {{Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition}},
  url          = {{http://dx.doi.org/10.1016/S0960-894X(03)00668-1}},
  doi          = {{10.1016/S0960-894X(03)00668-1}},
  volume       = {{13}},
  year         = {{2003}},
}