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Role du paracetamol dans la prise en charge des douleurs aigues

Kehlet, Henrik and Werner, Mads LU (2003) In Drugs 63(Special Issue 2). p.15-22
Abstract
Paracetamol (acetaminophen) has been shown to be an effective analgesic for the treatment of moderate pain where it is chiefly indicated, as shown in placebo-controlled studies in the perioperative setting and other acute pain states. In addition, an opioid-sparing effect has been demonstrated. No clinically relevant adverse effects are usually apparent with recommended doses. Paracetamol is an effective component in 'multimodal analgesia' in combination with morphine, weak opioids and non-steroidal anti-inflammatory drugs. Although most studies involve the perioperative setting, similar results have been obtained in other acute pain states, such as acute musculoskeletal pain, migraine, etc. In conclusion, paracetamol has a favourable... (More)
Paracetamol (acetaminophen) has been shown to be an effective analgesic for the treatment of moderate pain where it is chiefly indicated, as shown in placebo-controlled studies in the perioperative setting and other acute pain states. In addition, an opioid-sparing effect has been demonstrated. No clinically relevant adverse effects are usually apparent with recommended doses. Paracetamol is an effective component in 'multimodal analgesia' in combination with morphine, weak opioids and non-steroidal anti-inflammatory drugs. Although most studies involve the perioperative setting, similar results have been obtained in other acute pain states, such as acute musculoskeletal pain, migraine, etc. In conclusion, paracetamol has a favourable efficacy-tolerability profile and is therefore recommended as a basic, first-line analgesic in acute pain states and as a valuable component in multimodal analgesia. (Less)
Please use this url to cite or link to this publication:
author
alternative title
[Role of paracetamol in the acute pain management]
publishing date
type
Contribution to journal
publication status
published
subject
in
Drugs
volume
63
issue
Special Issue 2
pages
15 - 22
publisher
Adis International
external identifiers
  • pmid:14758787
  • scopus:0142147054
ISSN
0012-6667
language
French
LU publication?
no
id
82a2adbf-aba2-421c-afe5-14b718c539da (old id 1128098)
date added to LUP
2008-06-04 11:24:20
date last changed
2018-07-15 04:05:56
@article{82a2adbf-aba2-421c-afe5-14b718c539da,
  abstract     = {Paracetamol (acetaminophen) has been shown to be an effective analgesic for the treatment of moderate pain where it is chiefly indicated, as shown in placebo-controlled studies in the perioperative setting and other acute pain states. In addition, an opioid-sparing effect has been demonstrated. No clinically relevant adverse effects are usually apparent with recommended doses. Paracetamol is an effective component in 'multimodal analgesia' in combination with morphine, weak opioids and non-steroidal anti-inflammatory drugs. Although most studies involve the perioperative setting, similar results have been obtained in other acute pain states, such as acute musculoskeletal pain, migraine, etc. In conclusion, paracetamol has a favourable efficacy-tolerability profile and is therefore recommended as a basic, first-line analgesic in acute pain states and as a valuable component in multimodal analgesia.},
  author       = {Kehlet, Henrik and Werner, Mads},
  issn         = {0012-6667},
  language     = {fre},
  number       = {Special Issue 2},
  pages        = {15--22},
  publisher    = {Adis International},
  series       = {Drugs},
  title        = {Role du paracetamol dans la prise en charge des douleurs aigues},
  volume       = {63},
  year         = {2003},
}