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Galanin expression in sensory neurons after nerve compression or transection.

Dahlin, Lars LU ; Stenberg, Lena LU and Kanje, Martin LU (2003) In NeuroReport 14(3). p.359-362
Abstract
Galanin is probably involved in nociceptive sensory processing in spinal cord. We investigated whether a common injury, peripheral nerve compression, induced up-regulation of galanin (immunocytochemistry) in sensory neurons in rats 6 or 14 days post-injury and compared the response with other nerve injuries. Sciatic nerve compression increased the number of galanin positive sensory neurons as compared to uninjured and contralateral dorsal root ganglia. Complete transection was more efficient than a partial transection and a slight compression injury as an inducer of galanin. Mainly small diameter sensory neurons became positive but also some large diameter neurons. We conclude that nerve compression up-regulates galanin in sensory neurons.... (More)
Galanin is probably involved in nociceptive sensory processing in spinal cord. We investigated whether a common injury, peripheral nerve compression, induced up-regulation of galanin (immunocytochemistry) in sensory neurons in rats 6 or 14 days post-injury and compared the response with other nerve injuries. Sciatic nerve compression increased the number of galanin positive sensory neurons as compared to uninjured and contralateral dorsal root ganglia. Complete transection was more efficient than a partial transection and a slight compression injury as an inducer of galanin. Mainly small diameter sensory neurons became positive but also some large diameter neurons. We conclude that nerve compression up-regulates galanin in sensory neurons. The extent of the induction could be related to the severity of nerve injury. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
14
issue
3
pages
359 - 362
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000181641800012
  • pmid:12634483
  • scopus:0344837703
ISSN
1473-558X
DOI
10.1097/01.wnr.0000058037.29600.b6
language
English
LU publication?
yes
id
0354fddd-c373-4961-99df-09c2032df460 (old id 112820)
alternative location
http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200303030-00012.htm
date added to LUP
2007-07-17 13:24:03
date last changed
2018-05-29 09:36:07
@article{0354fddd-c373-4961-99df-09c2032df460,
  abstract     = {Galanin is probably involved in nociceptive sensory processing in spinal cord. We investigated whether a common injury, peripheral nerve compression, induced up-regulation of galanin (immunocytochemistry) in sensory neurons in rats 6 or 14 days post-injury and compared the response with other nerve injuries. Sciatic nerve compression increased the number of galanin positive sensory neurons as compared to uninjured and contralateral dorsal root ganglia. Complete transection was more efficient than a partial transection and a slight compression injury as an inducer of galanin. Mainly small diameter sensory neurons became positive but also some large diameter neurons. We conclude that nerve compression up-regulates galanin in sensory neurons. The extent of the induction could be related to the severity of nerve injury.},
  author       = {Dahlin, Lars and Stenberg, Lena and Kanje, Martin},
  issn         = {1473-558X},
  language     = {eng},
  number       = {3},
  pages        = {359--362},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Galanin expression in sensory neurons after nerve compression or transection.},
  url          = {http://dx.doi.org/10.1097/01.wnr.0000058037.29600.b6},
  volume       = {14},
  year         = {2003},
}