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Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study

Bornman, Liza; Campbell, Sarah J; Fielding, Katherine; Bah, Boubacar; Sillah, Jackson; Gustafson, Per LU ; Manneh, Kebba; Lisse, Ida; Allen, Angela and Sirugo, Giorgio, et al. (2004) In Journal of Infectious Diseases 190(9). p.1631-1641
Abstract
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no... (More)
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
190
issue
9
pages
1631 - 1641
publisher
Oxford University Press
external identifiers
  • pmid:15478069
  • scopus:5444259819
ISSN
1537-6613
DOI
10.1086/424462
language
English
LU publication?
no
id
402110bb-d117-4a49-9f31-38846d1b2645 (old id 1129402)
date added to LUP
2008-06-12 15:49:33
date last changed
2017-12-03 03:37:09
@article{402110bb-d117-4a49-9f31-38846d1b2645,
  abstract     = {Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.},
  author       = {Bornman, Liza and Campbell, Sarah J and Fielding, Katherine and Bah, Boubacar and Sillah, Jackson and Gustafson, Per and Manneh, Kebba and Lisse, Ida and Allen, Angela and Sirugo, Giorgio and Sylla, Aissatou and Aaby, Peter and McAdam, Keith P W J and Bah-Sow, Oumou and Bennett, Steve},
  issn         = {1537-6613},
  language     = {eng},
  number       = {9},
  pages        = {1631--1641},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study},
  url          = {http://dx.doi.org/10.1086/424462},
  volume       = {190},
  year         = {2004},
}