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Nove matrix metaloproteinazy v cyklickem endometriu

Pilka, Radovan LU ; Kudela, M; Hansson, Stefan LU and Casslén, Bertil LU (2004) In Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne 69(4). p.262-266
Abstract
OBJECTIVE: To examine the expression pattern of some novel matrix metalloproteinases (MMPs) in cycling endometrium. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden. METHODS: We studied MMP-12, -16, -17, -19 and -26 mRNA in 39 normal endometrial samples obtained across the menstrual cycle. Based on histological examination, all specimens were classified according to an ideal 28 day menstrual cycle as early (n=8), mid (n=6) and late (n=7) proliferative phase, early (n=4), mid (n=4) and late (n=8) secretory phase and menstrual (n=3) phase. Cycle... (More)
OBJECTIVE: To examine the expression pattern of some novel matrix metalloproteinases (MMPs) in cycling endometrium. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden. METHODS: We studied MMP-12, -16, -17, -19 and -26 mRNA in 39 normal endometrial samples obtained across the menstrual cycle. Based on histological examination, all specimens were classified according to an ideal 28 day menstrual cycle as early (n=8), mid (n=6) and late (n=7) proliferative phase, early (n=4), mid (n=4) and late (n=8) secretory phase and menstrual (n=3) phase. Cycle variation was examined in frozen samples using in situ hybridization. RESULTS: Three distinct pattern of MMP mRNA expression were detected in cycling endometrium. MMP-12 was expressed predominantly in perimenstrual period, MMP-16, -17 and 19 were expressed throughout the cycle and MMP-26 was found to be maximal in periovulatory period. CONCLUSION: Different endometrial expression patterns of novel MMPs during menstrual cycle may indicate their specific roles for menstruation, endometrial growth and remodelling and implantation. (Less)
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alternative title
Novel matrix metalloproteinases in cycling endometrium
publishing date
type
Contribution to journal
publication status
published
subject
in
Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne
volume
69
issue
4
pages
262 - 266
publisher
Ceska Lekarska Spolecnost J. E. Purkyne
external identifiers
  • pmid:15369243
  • scopus:4043171229
ISSN
1210-7832
language
Other
LU publication?
yes
id
a2bc8bbf-3db3-45c3-b643-76a951e05f26 (old id 1129636)
date added to LUP
2008-06-18 09:38:21
date last changed
2017-08-13 04:19:15
@article{a2bc8bbf-3db3-45c3-b643-76a951e05f26,
  abstract     = {OBJECTIVE: To examine the expression pattern of some novel matrix metalloproteinases (MMPs) in cycling endometrium. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden. METHODS: We studied MMP-12, -16, -17, -19 and -26 mRNA in 39 normal endometrial samples obtained across the menstrual cycle. Based on histological examination, all specimens were classified according to an ideal 28 day menstrual cycle as early (n=8), mid (n=6) and late (n=7) proliferative phase, early (n=4), mid (n=4) and late (n=8) secretory phase and menstrual (n=3) phase. Cycle variation was examined in frozen samples using in situ hybridization. RESULTS: Three distinct pattern of MMP mRNA expression were detected in cycling endometrium. MMP-12 was expressed predominantly in perimenstrual period, MMP-16, -17 and 19 were expressed throughout the cycle and MMP-26 was found to be maximal in periovulatory period. CONCLUSION: Different endometrial expression patterns of novel MMPs during menstrual cycle may indicate their specific roles for menstruation, endometrial growth and remodelling and implantation.},
  author       = {Pilka, Radovan and Kudela, M and Hansson, Stefan and Casslén, Bertil},
  issn         = {1210-7832},
  language     = {mis},
  number       = {4},
  pages        = {262--266},
  publisher    = {Ceska Lekarska Spolecnost J. E. Purkyne},
  series       = {Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne},
  title        = {Nove matrix metaloproteinazy v cyklickem endometriu},
  volume       = {69},
  year         = {2004},
}