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Reduced anti-TNFalpha autoantibody levels coincide with flare in systemic lupus erythematosus

Sjowall, Christopher; Ernerudh, Jan; Bengtsson, Anders LU ; Sturfelt, Gunnar LU and Skogh, Thomas (2004) In Journal of Autoimmunity 22(4). p.315-323
Abstract
Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease... (More)
Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease activity index (SLEDAI) (r(2)=0.07, P<0.01), whereas anti-TGFbeta antibodies were raised in SLE and correlated positively to levels of complement factor C1q (r(2)=0.08, P<0.005). Generally raised anti-cytokine antibody levels and correlations to disease activity measures were found in one individual. Inverse correlations were found comparing SLEDAI scores and autoantibodies to TNFalpha (r(2)=0.92) and IL-6 (r(2)=0.86) and positive correlations were found between levels of anti-TNFalpha and C1q (r(2)=0.86) and C3 (r(2)=0.90). We show, for the first time, a coincidence between reduced anti-TNFalpha autoantibody levels and disease exacerbation in SLE, which is of interest regarding aetiopathogenesis and disease control. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Systemic lupus erythematosus, Immunoregulation, Disease activity, Anti-cytokine antibodies, SLEDAI, Tumour necrosis factor greek small letter alpha
in
Journal of Autoimmunity
volume
22
issue
4
pages
315 - 323
publisher
Elsevier
external identifiers
  • pmid:15120755
  • wos:000222018000006
  • scopus:16544381633
ISSN
0896-8411
DOI
10.1016/j.jaut.2004.02.003
language
English
LU publication?
yes
id
121432d1-aa9b-4349-af91-ab75e1dc8373 (old id 1129777)
date added to LUP
2008-06-18 12:20:21
date last changed
2017-05-21 03:41:19
@article{121432d1-aa9b-4349-af91-ab75e1dc8373,
  abstract     = {Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P&lt;0.001) as well as to NHS (P&lt;0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease activity index (SLEDAI) (r(2)=0.07, P&lt;0.01), whereas anti-TGFbeta antibodies were raised in SLE and correlated positively to levels of complement factor C1q (r(2)=0.08, P&lt;0.005). Generally raised anti-cytokine antibody levels and correlations to disease activity measures were found in one individual. Inverse correlations were found comparing SLEDAI scores and autoantibodies to TNFalpha (r(2)=0.92) and IL-6 (r(2)=0.86) and positive correlations were found between levels of anti-TNFalpha and C1q (r(2)=0.86) and C3 (r(2)=0.90). We show, for the first time, a coincidence between reduced anti-TNFalpha autoantibody levels and disease exacerbation in SLE, which is of interest regarding aetiopathogenesis and disease control.},
  author       = {Sjowall, Christopher and Ernerudh, Jan and Bengtsson, Anders and Sturfelt, Gunnar and Skogh, Thomas},
  issn         = {0896-8411},
  keyword      = {Systemic lupus erythematosus,Immunoregulation,Disease activity,Anti-cytokine antibodies,SLEDAI,Tumour necrosis factor greek small letter alpha},
  language     = {eng},
  number       = {4},
  pages        = {315--323},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {Reduced anti-TNFalpha autoantibody levels coincide with flare in systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1016/j.jaut.2004.02.003},
  volume       = {22},
  year         = {2004},
}