Reduced anti-TNFalpha autoantibody levels coincide with flare in systemic lupus erythematosus
(2004) In Journal of Autoimmunity 22(4). p.315-323- Abstract
- Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease... (More)
- Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease activity index (SLEDAI) (r(2)=0.07, P<0.01), whereas anti-TGFbeta antibodies were raised in SLE and correlated positively to levels of complement factor C1q (r(2)=0.08, P<0.005). Generally raised anti-cytokine antibody levels and correlations to disease activity measures were found in one individual. Inverse correlations were found comparing SLEDAI scores and autoantibodies to TNFalpha (r(2)=0.92) and IL-6 (r(2)=0.86) and positive correlations were found between levels of anti-TNFalpha and C1q (r(2)=0.86) and C3 (r(2)=0.90). We show, for the first time, a coincidence between reduced anti-TNFalpha autoantibody levels and disease exacerbation in SLE, which is of interest regarding aetiopathogenesis and disease control. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1129777
- author
- Sjowall, Christopher ; Ernerudh, Jan ; Bengtsson, Anders LU ; Sturfelt, Gunnar LU and Skogh, Thomas
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Systemic lupus erythematosus, Immunoregulation, Disease activity, Anti-cytokine antibodies, SLEDAI, Tumour necrosis factor greek small letter alpha
- in
- Journal of Autoimmunity
- volume
- 22
- issue
- 4
- pages
- 315 - 323
- publisher
- Elsevier
- external identifiers
-
- pmid:15120755
- wos:000222018000006
- scopus:16544381633
- ISSN
- 0896-8411
- DOI
- 10.1016/j.jaut.2004.02.003
- language
- English
- LU publication?
- yes
- id
- 121432d1-aa9b-4349-af91-ab75e1dc8373 (old id 1129777)
- date added to LUP
- 2016-04-01 12:17:04
- date last changed
- 2022-03-21 02:01:11
@article{121432d1-aa9b-4349-af91-ab75e1dc8373, abstract = {{Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of aetiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease activity index (SLEDAI) (r(2)=0.07, P<0.01), whereas anti-TGFbeta antibodies were raised in SLE and correlated positively to levels of complement factor C1q (r(2)=0.08, P<0.005). Generally raised anti-cytokine antibody levels and correlations to disease activity measures were found in one individual. Inverse correlations were found comparing SLEDAI scores and autoantibodies to TNFalpha (r(2)=0.92) and IL-6 (r(2)=0.86) and positive correlations were found between levels of anti-TNFalpha and C1q (r(2)=0.86) and C3 (r(2)=0.90). We show, for the first time, a coincidence between reduced anti-TNFalpha autoantibody levels and disease exacerbation in SLE, which is of interest regarding aetiopathogenesis and disease control.}}, author = {{Sjowall, Christopher and Ernerudh, Jan and Bengtsson, Anders and Sturfelt, Gunnar and Skogh, Thomas}}, issn = {{0896-8411}}, keywords = {{Systemic lupus erythematosus; Immunoregulation; Disease activity; Anti-cytokine antibodies; SLEDAI; Tumour necrosis factor greek small letter alpha}}, language = {{eng}}, number = {{4}}, pages = {{315--323}}, publisher = {{Elsevier}}, series = {{Journal of Autoimmunity}}, title = {{Reduced anti-TNFalpha autoantibody levels coincide with flare in systemic lupus erythematosus}}, url = {{http://dx.doi.org/10.1016/j.jaut.2004.02.003}}, doi = {{10.1016/j.jaut.2004.02.003}}, volume = {{22}}, year = {{2004}}, }