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Basic science of peripheral nerve repair: Wallerian degeneration/growth cone

Dahlin, Lars LU and Brandt, Jerker LU (2004) In Operative Techniques in Orthopaedics 14(2). p.138-145
Abstract
Trauma to a peripheral nerve trunk is a complex injury because it involves not only repair processes locally at the peripheral level, but it also engages repair and compensation mechanisms at central levels. The main actor is the fascinating and unique neuron with its supporting cells, which consist mainly of Schwann cells. In the neuron and in the Schwann cells, intracellular signaling mechanisms are initiated by the peripheral nerve injury and aim to turn the intracellular processes into a regenerative and proliferative state. The intracellular signaling mechanism is called signal transduction and works along the entire neuron, including the intracellular axonal transport system. A very delicate interaction occurs between the growth... (More)
Trauma to a peripheral nerve trunk is a complex injury because it involves not only repair processes locally at the peripheral level, but it also engages repair and compensation mechanisms at central levels. The main actor is the fascinating and unique neuron with its supporting cells, which consist mainly of Schwann cells. In the neuron and in the Schwann cells, intracellular signaling mechanisms are initiated by the peripheral nerve injury and aim to turn the intracellular processes into a regenerative and proliferative state. The intracellular signaling mechanism is called signal transduction and works along the entire neuron, including the intracellular axonal transport system. A very delicate interaction occurs between the growth cones formed by the distal tip of the outgrowing axons and the environment into which the axons grow. A large number of changes occur in this environment due to the process of Wallerian degeneration caused by the injury. A thorough knowledge of the cellular and molecular repair mechanisms after peripheral nerve injury is the basis on which we can build new research with the aim to improve results after this devastating injury, because there are limitations in the pure surgical treatment of peripheral injury. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Operative Techniques in Orthopaedics
volume
14
issue
2
pages
138 - 145
publisher
Elsevier
external identifiers
  • scopus:7544223702
ISSN
1048-6666
DOI
10.1053/j.oto.2004.06.004
language
English
LU publication?
yes
id
68830f64-5eb9-46c8-8f41-82b2292e2232 (old id 1130439)
date added to LUP
2008-06-13 11:07:23
date last changed
2017-01-01 06:49:16
@article{68830f64-5eb9-46c8-8f41-82b2292e2232,
  abstract     = {Trauma to a peripheral nerve trunk is a complex injury because it involves not only repair processes locally at the peripheral level, but it also engages repair and compensation mechanisms at central levels. The main actor is the fascinating and unique neuron with its supporting cells, which consist mainly of Schwann cells. In the neuron and in the Schwann cells, intracellular signaling mechanisms are initiated by the peripheral nerve injury and aim to turn the intracellular processes into a regenerative and proliferative state. The intracellular signaling mechanism is called signal transduction and works along the entire neuron, including the intracellular axonal transport system. A very delicate interaction occurs between the growth cones formed by the distal tip of the outgrowing axons and the environment into which the axons grow. A large number of changes occur in this environment due to the process of Wallerian degeneration caused by the injury. A thorough knowledge of the cellular and molecular repair mechanisms after peripheral nerve injury is the basis on which we can build new research with the aim to improve results after this devastating injury, because there are limitations in the pure surgical treatment of peripheral injury.},
  author       = {Dahlin, Lars and Brandt, Jerker},
  issn         = {1048-6666},
  language     = {eng},
  number       = {2},
  pages        = {138--145},
  publisher    = {Elsevier},
  series       = {Operative Techniques in Orthopaedics},
  title        = {Basic science of peripheral nerve repair: Wallerian degeneration/growth cone},
  url          = {http://dx.doi.org/10.1053/j.oto.2004.06.004},
  volume       = {14},
  year         = {2004},
}