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The biology of nerve injury and repair

Dahlin, Lars LU (2004) In Journal of the American Society for Surgery of the Hand 4(3). p.143-155
Abstract
A peripheral nerve injury has a profound impact on the patient’s life and such an injury causes high costs for society. A peripheral nerve injury is a very complex injury because it involves both peripheral and central components of the nervous system all the way from targets at muscle and skin receptors up to the brain. In the neuron and its supporting cells—mainly Schwann cells—there are numerous steps in intracellular signaling, signal transduction, that are initiated by the injury with the aim of putting the neuron and the Schwann cells into a regenerative and proliferative condition, respectively. The present article focuses on the basic reactions of the neuron and the Schwann cells during injury and regeneration from a neurobiologic... (More)
A peripheral nerve injury has a profound impact on the patient’s life and such an injury causes high costs for society. A peripheral nerve injury is a very complex injury because it involves both peripheral and central components of the nervous system all the way from targets at muscle and skin receptors up to the brain. In the neuron and its supporting cells—mainly Schwann cells—there are numerous steps in intracellular signaling, signal transduction, that are initiated by the injury with the aim of putting the neuron and the Schwann cells into a regenerative and proliferative condition, respectively. The present article focuses on the basic reactions of the neuron and the Schwann cells during injury and regeneration from a neurobiologic viewpoint. Greater future understanding about the signal transduction mechanisms in neurons and Schwann cells will help to develop pharmacologic strategies in addition to the current surgical treatment options. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the American Society for Surgery of the Hand
volume
4
issue
3
pages
143 - 155
publisher
Elsevier
external identifiers
  • scopus:4544287868
ISSN
1531-0914
DOI
10.1016/j.jassh.2004.06.006
language
English
LU publication?
yes
id
ce7eeab5-c1a7-40b9-a143-9164fb6b96a8 (old id 1130441)
date added to LUP
2008-06-13 11:11:38
date last changed
2017-05-28 04:24:41
@article{ce7eeab5-c1a7-40b9-a143-9164fb6b96a8,
  abstract     = {A peripheral nerve injury has a profound impact on the patient’s life and such an injury causes high costs for society. A peripheral nerve injury is a very complex injury because it involves both peripheral and central components of the nervous system all the way from targets at muscle and skin receptors up to the brain. In the neuron and its supporting cells—mainly Schwann cells—there are numerous steps in intracellular signaling, signal transduction, that are initiated by the injury with the aim of putting the neuron and the Schwann cells into a regenerative and proliferative condition, respectively. The present article focuses on the basic reactions of the neuron and the Schwann cells during injury and regeneration from a neurobiologic viewpoint. Greater future understanding about the signal transduction mechanisms in neurons and Schwann cells will help to develop pharmacologic strategies in addition to the current surgical treatment options.},
  author       = {Dahlin, Lars},
  issn         = {1531-0914},
  language     = {eng},
  number       = {3},
  pages        = {143--155},
  publisher    = {Elsevier},
  series       = {Journal of the American Society for Surgery of the Hand},
  title        = {The biology of nerve injury and repair},
  url          = {http://dx.doi.org/10.1016/j.jassh.2004.06.006},
  volume       = {4},
  year         = {2004},
}