The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population
(2019) In Scientific Reports 9(1). p.16208-16208- Abstract
Red Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population. RDW was measured in 27,063 participants (aged 45-73 years) from the population-based Malmö Diet and Cancer cohort. After a follow-up of 19.8 ± 5.5 years, Cox proportional hazards regression analysis was used to study the relationship between RDW and all-cause and cause-specific mortality, with adjustment for confounding factors. A total of 9388 individuals (4715 men and 4673 women) died during the follow up. High RDW was... (More)
Red Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population. RDW was measured in 27,063 participants (aged 45-73 years) from the population-based Malmö Diet and Cancer cohort. After a follow-up of 19.8 ± 5.5 years, Cox proportional hazards regression analysis was used to study the relationship between RDW and all-cause and cause-specific mortality, with adjustment for confounding factors. A total of 9388 individuals (4715 men and 4673 women) died during the follow up. High RDW was significantly associated with all-cause mortality (HR, 4th vs. 1st quartile: 1.34, 95%CI: 1.24-1.45), cancer mortality (HR: 1.27, 95%CI: 1.12-1.44), CVD mortality (HR: 1.39, 95%CI: 1.21-1.59), and respiratory disease mortality (HR: 1.47, 95%CI: 1.06-2.03). The C-statistic increased significantly from 0.732 to 0.737 when adding RDW to a model adjusted for age and sex. There was a significant interaction between RDW and BMI with respect to all-cause mortality. We concluded that RDW is associated with mortality and propose that high RDW is a significant, but non-specific marker of mortality risk in the general population.
(Less)
- author
- Pan, Jingxue LU ; Borné, Yan LU and Engström, Gunnar LU
- organization
- publishing date
- 2019-11-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 9
- issue
- 1
- pages
- 16208 - 16208
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85074683806
- pmid:31700048
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-019-52708-2
- language
- English
- LU publication?
- yes
- id
- 1130487e-9fdd-44d0-a788-23df2d8b88b2
- date added to LUP
- 2020-05-08 15:38:14
- date last changed
- 2024-02-16 16:23:31
@article{1130487e-9fdd-44d0-a788-23df2d8b88b2, abstract = {{<p>Red Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population. RDW was measured in 27,063 participants (aged 45-73 years) from the population-based Malmö Diet and Cancer cohort. After a follow-up of 19.8 ± 5.5 years, Cox proportional hazards regression analysis was used to study the relationship between RDW and all-cause and cause-specific mortality, with adjustment for confounding factors. A total of 9388 individuals (4715 men and 4673 women) died during the follow up. High RDW was significantly associated with all-cause mortality (HR, 4th vs. 1st quartile: 1.34, 95%CI: 1.24-1.45), cancer mortality (HR: 1.27, 95%CI: 1.12-1.44), CVD mortality (HR: 1.39, 95%CI: 1.21-1.59), and respiratory disease mortality (HR: 1.47, 95%CI: 1.06-2.03). The C-statistic increased significantly from 0.732 to 0.737 when adding RDW to a model adjusted for age and sex. There was a significant interaction between RDW and BMI with respect to all-cause mortality. We concluded that RDW is associated with mortality and propose that high RDW is a significant, but non-specific marker of mortality risk in the general population.</p>}}, author = {{Pan, Jingxue and Borné, Yan and Engström, Gunnar}}, issn = {{2045-2322}}, language = {{eng}}, month = {{11}}, number = {{1}}, pages = {{16208--16208}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population}}, url = {{http://dx.doi.org/10.1038/s41598-019-52708-2}}, doi = {{10.1038/s41598-019-52708-2}}, volume = {{9}}, year = {{2019}}, }