Advanced

Electroconvulsive seizures induce angiogenesis in adult rat hippocampus

Hellsten, Johan LU ; West, M J; Arvidsson, Andreas LU ; Ekstrand, Joakim LU ; Jansson, Linda LU ; Wennström, Malin LU and Tingström, Anders LU (2005) In Biological Psychiatry 58(11). p.871-878
Abstract
Background: Electroconvulsive seizure (ECS)-treatment, a model for electroconvulsive therapy (ECT) has been shown to induce proliferation of endothelial cells in the dentate gyrus (DG) of adult rats. Here we quantified the net angiogenic response after hypoxia a known inducer of aniogenesis. Therefore we also examined the effect of oxygenation on ECS-induced proliferation of endothelial cells. Methods: Total endothelial cell numbers and vessel length were estimated utilizing design based stereological analysis methods. Endothelial cell proliferation in the DG after ECS with or withouy oxygenation was assessed using bromodeoxyuridine. Results: The total number of endothelial cell numbers and vessels lenght was increased. Oxygenation did not... (More)
Background: Electroconvulsive seizure (ECS)-treatment, a model for electroconvulsive therapy (ECT) has been shown to induce proliferation of endothelial cells in the dentate gyrus (DG) of adult rats. Here we quantified the net angiogenic response after hypoxia a known inducer of aniogenesis. Therefore we also examined the effect of oxygenation on ECS-induced proliferation of endothelial cells. Methods: Total endothelial cell numbers and vessel length were estimated utilizing design based stereological analysis methods. Endothelial cell proliferation in the DG after ECS with or withouy oxygenation was assessed using bromodeoxyuridine. Results: The total number of endothelial cell numbers and vessels lenght was increased. Oxygenation did not abolish the ECS-induced proliferation of endothelial cells in the DG. Conclusions: ECS-treatment induces a dramatic increase in endothelial cell proliferation leading to a 30% increase in the total numberof endothelial cells. The increase in cell number resulted i na 16% increase in vessel length. These findings raise the possibility that similar vascular growth is induced by clinically administered ECT. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ECT, seizures, angiogenesis, hippocampus, major depression
in
Biological Psychiatry
volume
58
issue
11
pages
871 - 878
publisher
Society of Biological Psychiatry Published by Elsevier Inc.
external identifiers
  • wos:000234035900005
  • scopus:29044431613
ISSN
0006-3223
DOI
10.1016/j.biopsych.2005.05.023
language
English
LU publication?
yes
id
ddd73624-c65e-4385-a70a-feb820732683 (old id 1132036)
date added to LUP
2008-06-18 12:13:18
date last changed
2017-08-27 04:10:52
@article{ddd73624-c65e-4385-a70a-feb820732683,
  abstract     = {Background: Electroconvulsive seizure (ECS)-treatment, a model for electroconvulsive therapy (ECT) has been shown to induce proliferation of endothelial cells in the dentate gyrus (DG) of adult rats. Here we quantified the net angiogenic response after hypoxia a known inducer of aniogenesis. Therefore we also examined the effect of oxygenation on ECS-induced proliferation of endothelial cells. Methods: Total endothelial cell numbers and vessel length were estimated utilizing design based stereological analysis methods. Endothelial cell proliferation in the DG after ECS with or withouy oxygenation was assessed using bromodeoxyuridine. Results: The total number of endothelial cell numbers and vessels lenght was increased. Oxygenation did not abolish the ECS-induced proliferation of endothelial cells in the DG. Conclusions: ECS-treatment induces a dramatic increase in endothelial cell proliferation leading to a 30% increase in the total numberof endothelial cells. The increase in cell number resulted i na 16% increase in vessel length. These findings raise the possibility that similar vascular growth is induced by clinically administered ECT.},
  author       = {Hellsten, Johan and West, M J and Arvidsson, Andreas and Ekstrand, Joakim and Jansson, Linda and Wennström, Malin and Tingström, Anders},
  issn         = {0006-3223},
  keyword      = {ECT,seizures,angiogenesis,hippocampus,major depression},
  language     = {eng},
  number       = {11},
  pages        = {871--878},
  publisher    = {Society of Biological Psychiatry Published by Elsevier Inc.},
  series       = {Biological Psychiatry},
  title        = {Electroconvulsive seizures induce angiogenesis in adult rat hippocampus},
  url          = {http://dx.doi.org/10.1016/j.biopsych.2005.05.023},
  volume       = {58},
  year         = {2005},
}