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Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin

Matheu, Victor LU ; Perez, Eva; Hernandez, Marta; Diaz, Elisa; Darias, Ricardo; Gonzalez, Abel; Garcia, Jose C; Sanchez, Inmaculada; Feliciano, Laura and Caballero, Agueda, et al. (2005) In Clinical and Molecular Allergy 3(16).
Abstract
A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions immediately after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.
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publication status
published
subject
in
Clinical and Molecular Allergy
volume
3
issue
16
publisher
BioMed Central
external identifiers
  • pmid:16375762
  • scopus:30044435979
ISSN
1476-7961
DOI
10.1186/1476-7961-3-16
language
English
LU publication?
yes
id
b5687512-3f28-49da-87dd-8b5321407430 (old id 1132265)
date added to LUP
2008-06-30 10:45:27
date last changed
2017-10-29 04:23:52
@article{b5687512-3f28-49da-87dd-8b5321407430,
  abstract     = {A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions immediately after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.},
  author       = {Matheu, Victor and Perez, Eva and Hernandez, Marta and Diaz, Elisa and Darias, Ricardo and Gonzalez, Abel and Garcia, Jose C and Sanchez, Inmaculada and Feliciano, Laura and Caballero, Agueda and de la Torre, Fernando},
  issn         = {1476-7961},
  language     = {eng},
  number       = {16},
  publisher    = {BioMed Central},
  series       = {Clinical and Molecular Allergy},
  title        = {Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin},
  url          = {http://dx.doi.org/10.1186/1476-7961-3-16},
  volume       = {3},
  year         = {2005},
}