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Gastric bypass surgery does not increase susceptibility to Helicobacter pylori infection in the stomach of rat or mouse

Stenstrom, Bjorn; Loseth, Kirsti; Bevanger, Lars; Sturegård, Erik LU ; Wadström, Torkel LU and Chen, Duan (2005) In Inflammopharmacology 13(1-3). p.229-236
Abstract
Gastric bypass is a clinical option for obesity surgery. An increased susceptibility to Helicobacter pylori infection in the bypassed stomach has been speculated. The aim of the present study was to examine the susceptibility of the bypassed stomach to H. pylori infection in rats and mice. Adult Sprague-Dawley and Wistar rats and NMRI mice were subjected to either gastric bypass or laparotomy only as control. The animals were inoculated with the CagA- and VacA- positive H. pylori strain 67/21 (not mouse-adapted) in the first experiment and with 9 additional isolates in the second, by injection into the bypassed stomach or the control stomach during surgery. The stomach of each animal was collected for H. pylori culture 2-3 weeks later.... (More)
Gastric bypass is a clinical option for obesity surgery. An increased susceptibility to Helicobacter pylori infection in the bypassed stomach has been speculated. The aim of the present study was to examine the susceptibility of the bypassed stomach to H. pylori infection in rats and mice. Adult Sprague-Dawley and Wistar rats and NMRI mice were subjected to either gastric bypass or laparotomy only as control. The animals were inoculated with the CagA- and VacA- positive H. pylori strain 67/21 (not mouse-adapted) in the first experiment and with 9 additional isolates in the second, by injection into the bypassed stomach or the control stomach during surgery. The stomach of each animal was collected for H. pylori culture 2-3 weeks later. While all the rats were H. pylori negative, 54% of gastric bypassed mice and 75% of controls were positive (P = 0.4). We conclude that susceptibility to H. pylori infection in the stomach is not increased by gastric bypass surgery. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inflammopharmacology
volume
13
issue
1-3
pages
229 - 236
publisher
Kluwer
external identifiers
  • pmid:16259742
  • scopus:27744579599
ISSN
1568-5608
DOI
10.1163/156856005774423791
language
English
LU publication?
yes
id
42f0c784-540b-475f-86de-13639f1520a9 (old id 1133007)
date added to LUP
2008-06-23 13:44:53
date last changed
2017-01-01 04:23:18
@article{42f0c784-540b-475f-86de-13639f1520a9,
  abstract     = {Gastric bypass is a clinical option for obesity surgery. An increased susceptibility to Helicobacter pylori infection in the bypassed stomach has been speculated. The aim of the present study was to examine the susceptibility of the bypassed stomach to H. pylori infection in rats and mice. Adult Sprague-Dawley and Wistar rats and NMRI mice were subjected to either gastric bypass or laparotomy only as control. The animals were inoculated with the CagA- and VacA- positive H. pylori strain 67/21 (not mouse-adapted) in the first experiment and with 9 additional isolates in the second, by injection into the bypassed stomach or the control stomach during surgery. The stomach of each animal was collected for H. pylori culture 2-3 weeks later. While all the rats were H. pylori negative, 54% of gastric bypassed mice and 75% of controls were positive (P = 0.4). We conclude that susceptibility to H. pylori infection in the stomach is not increased by gastric bypass surgery.},
  author       = {Stenstrom, Bjorn and Loseth, Kirsti and Bevanger, Lars and Sturegård, Erik and Wadström, Torkel and Chen, Duan},
  issn         = {1568-5608},
  language     = {eng},
  number       = {1-3},
  pages        = {229--236},
  publisher    = {Kluwer},
  series       = {Inflammopharmacology},
  title        = {Gastric bypass surgery does not increase susceptibility to Helicobacter pylori infection in the stomach of rat or mouse},
  url          = {http://dx.doi.org/10.1163/156856005774423791},
  volume       = {13},
  year         = {2005},
}