Advanced

Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.

Åkesson, K; Nyström, L; Färnkvist, L; Ostman, J; Lernmark, Åke LU and Kockum, I (2005) In Diabetic Medicine 22(11). p.1551-1557
Abstract
Aims This study aimed to determine the risk of developing diabetes among relatives of patients diagnosed between 15 and 34 years of age who were treated with insulin. Our second aim was to determine whether there was a difference in risk of diabetes between relatives of male and female patients.



Methods A questionnaire was sent to patients in the Diabetes Incidence Study in Sweden registry diagnosed between 1983 and 1993 to determine the presence of first-degree relatives with diabetes.



Results In 3087 index patients treated with insulin, 17.8% (95% confidence interval 16.5, 19.2) had a first-degree relative (excluding offspring) treated with insulin, the frequency being higher in female (19.8%) than... (More)
Aims This study aimed to determine the risk of developing diabetes among relatives of patients diagnosed between 15 and 34 years of age who were treated with insulin. Our second aim was to determine whether there was a difference in risk of diabetes between relatives of male and female patients.



Methods A questionnaire was sent to patients in the Diabetes Incidence Study in Sweden registry diagnosed between 1983 and 1993 to determine the presence of first-degree relatives with diabetes.



Results In 3087 index patients treated with insulin, 17.8% (95% confidence interval 16.5, 19.2) had a first-degree relative (excluding offspring) treated with insulin, the frequency being higher in female (19.8%) than in male (16.5%, P = 0.018) patients. A total of 10.7% had a parent treated with insulin. The prevalence of insulin-treated diabetes was higher among parents of female (12.5%) than of male (9.5%), insulin-treated index patients (P = 0.0068). A similar difference was observed using life table analysis (P = 0.0025), which also showed that the risk by 63 years of age was 7.6% for parents of female and 4.9% for parents of male insulin-treated index patients. In insulin-treated index patients, 8.4% had a sibling with insulin-treated diabetes.



Conclusions We conclude that the risk for relatives of women with insulin-treated diabetes was higher than for relatives of insulin-treated male patients. We suggest that greater genetic susceptibility is required for females compared with males in the 15–34 age group in order to develop diabetes and hence females might carry more diabetes genes since more of their relatives also develop diabetes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic Medicine
volume
22
issue
11
pages
1551 - 1557
publisher
Wiley-Blackwell
external identifiers
  • Scopus:27844544635
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2005.01694.x
language
English
LU publication?
yes
id
695d512c-11b1-4604-940a-bb7b83c883a2 (old id 1133069)
date added to LUP
2008-06-19 12:59:21
date last changed
2017-01-01 08:08:02
@article{695d512c-11b1-4604-940a-bb7b83c883a2,
  abstract     = {Aims This study aimed to determine the risk of developing diabetes among relatives of patients diagnosed between 15 and 34 years of age who were treated with insulin. Our second aim was to determine whether there was a difference in risk of diabetes between relatives of male and female patients.<br/><br>
<br/><br>
Methods A questionnaire was sent to patients in the Diabetes Incidence Study in Sweden registry diagnosed between 1983 and 1993 to determine the presence of first-degree relatives with diabetes.<br/><br>
<br/><br>
Results In 3087 index patients treated with insulin, 17.8% (95% confidence interval 16.5, 19.2) had a first-degree relative (excluding offspring) treated with insulin, the frequency being higher in female (19.8%) than in male (16.5%, P = 0.018) patients. A total of 10.7% had a parent treated with insulin. The prevalence of insulin-treated diabetes was higher among parents of female (12.5%) than of male (9.5%), insulin-treated index patients (P = 0.0068). A similar difference was observed using life table analysis (P = 0.0025), which also showed that the risk by 63 years of age was 7.6% for parents of female and 4.9% for parents of male insulin-treated index patients. In insulin-treated index patients, 8.4% had a sibling with insulin-treated diabetes.<br/><br>
<br/><br>
Conclusions We conclude that the risk for relatives of women with insulin-treated diabetes was higher than for relatives of insulin-treated male patients. We suggest that greater genetic susceptibility is required for females compared with males in the 15–34 age group in order to develop diabetes and hence females might carry more diabetes genes since more of their relatives also develop diabetes.},
  author       = {Åkesson, K and Nyström, L and Färnkvist, L and Ostman, J and Lernmark, Åke and Kockum, I},
  issn         = {1464-5491},
  language     = {eng},
  number       = {11},
  pages        = {1551--1557},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2005.01694.x},
  volume       = {22},
  year         = {2005},
}