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Innovations in serum and urine markers in prostate cancer current European research in the P-Mark project

van Gils, M P M Q; Stenman, U H; Schalken, J A; Schroder, F H; Luider, T M; Lilja, Hans LU ; Bjartell, Anders LU ; Hamdy, F C; Pettersson, K S I and Bischoff, R, et al. (2005) In European Urology 48(6). p.1031-1041
Abstract
An overview is given of serum and urine prostate cancer markers that are currently under investigation and subsequently the P-Mark project is introduced. There are many markers showing promise to overcome the limitations of prostate specific antigen (PSA). Eventually, these markers should be able to increase the specificity in diagnosis, differentiate between harmless and aggressive disease and identify progression towards androgen independence at an early stage. In the P-Mark project, several recently developed, promising markers will be evaluated using clinically well-defined biorepositories. Following successful evaluation, these markers will be validated on a sample set derived from two large, European, prostate cancer studies and used... (More)
An overview is given of serum and urine prostate cancer markers that are currently under investigation and subsequently the P-Mark project is introduced. There are many markers showing promise to overcome the limitations of prostate specific antigen (PSA). Eventually, these markers should be able to increase the specificity in diagnosis, differentiate between harmless and aggressive disease and identify progression towards androgen independence at an early stage. In the P-Mark project, several recently developed, promising markers will be evaluated using clinically well-defined biorepositories. Following successful evaluation, these markers will be validated on a sample set derived from two large, European, prostate cancer studies and used for the identification of special risk groups in the general population. In addition, novel markers will be identified in the same biorepositories by different mass spectrometry techniques. (Less)
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Contribution to journal
publication status
published
subject
keywords
Prostatic neoplasms, Tumor markers, Biological, Serum, Urine, Diagnosis, Prognosis
in
European Urology
volume
48
issue
6
pages
1031 - 1041
publisher
Elsevier
external identifiers
  • pmid:16054748
  • scopus:27844585571
ISSN
1873-7560
DOI
10.1016/j.eururo.2005.06.009
language
English
LU publication?
yes
id
57daa0ee-ed1e-450e-87ed-49c40c580e92 (old id 1133152)
date added to LUP
2008-06-19 11:23:21
date last changed
2017-01-01 07:20:09
@article{57daa0ee-ed1e-450e-87ed-49c40c580e92,
  abstract     = {An overview is given of serum and urine prostate cancer markers that are currently under investigation and subsequently the P-Mark project is introduced. There are many markers showing promise to overcome the limitations of prostate specific antigen (PSA). Eventually, these markers should be able to increase the specificity in diagnosis, differentiate between harmless and aggressive disease and identify progression towards androgen independence at an early stage. In the P-Mark project, several recently developed, promising markers will be evaluated using clinically well-defined biorepositories. Following successful evaluation, these markers will be validated on a sample set derived from two large, European, prostate cancer studies and used for the identification of special risk groups in the general population. In addition, novel markers will be identified in the same biorepositories by different mass spectrometry techniques.},
  author       = {van Gils, M P M Q and Stenman, U H and Schalken, J A and Schroder, F H and Luider, T M and Lilja, Hans and Bjartell, Anders and Hamdy, F C and Pettersson, K S I and Bischoff, R and Takalo, H and Nilsson, O and Mulders, P F A and Bangma, C H},
  issn         = {1873-7560},
  keyword      = {Prostatic neoplasms,Tumor markers,Biological,Serum,Urine,Diagnosis,Prognosis},
  language     = {eng},
  number       = {6},
  pages        = {1031--1041},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Innovations in serum and urine markers in prostate cancer current European research in the P-Mark project},
  url          = {http://dx.doi.org/10.1016/j.eururo.2005.06.009},
  volume       = {48},
  year         = {2005},
}