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Sex specific expression of progesterone receptor in mouse lower urinary tract

Savolainen, S; Santti, R; Streng, T; Gustafsson, J-A; Härkönen, Pirkko LU and Makela, S (2005) In Molecular and Cellular Endocrinology 230(1-2). p.17-21
Abstract
Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner.



PR was found to be co-expressed with ERgreek small letter alpha in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERgreek small letter alpha. In... (More)
Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner.



PR was found to be co-expressed with ERgreek small letter alpha in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERgreek small letter alpha. In male urethra, PR was co-expressed with ERβ in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Progesterone receptor, Urinary tract, Estrogen receptor null mice
in
Molecular and Cellular Endocrinology
volume
230
issue
1-2
pages
17 - 21
publisher
Elsevier
external identifiers
  • scopus:12344330629
ISSN
1872-8057
DOI
10.1016/j.mce.2004.11.008
language
English
LU publication?
yes
id
cc47fcc2-591b-42af-a9d5-920589536b00 (old id 1133678)
date added to LUP
2008-06-17 15:53:54
date last changed
2017-01-01 05:12:13
@article{cc47fcc2-591b-42af-a9d5-920589536b00,
  abstract     = {Progesterone receptor (PR) was investigated immunohistochemically in the lower urinary tract of the male and female mouse. Estrogen receptor (ER)-subtype-deficient mice (ERKO, BERKO) were used to determine the possible regulation of PR expression in an ER-subtype-specific manner.<br/><br>
<br/><br>
PR was found to be co-expressed with ERgreek small letter alpha in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERgreek small letter alpha. In male urethra, PR was co-expressed with ERβ in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain.},
  author       = {Savolainen, S and Santti, R and Streng, T and Gustafsson, J-A and Härkönen, Pirkko and Makela, S},
  issn         = {1872-8057},
  keyword      = {Progesterone receptor,Urinary tract,Estrogen receptor null mice},
  language     = {eng},
  number       = {1-2},
  pages        = {17--21},
  publisher    = {Elsevier},
  series       = {Molecular and Cellular Endocrinology},
  title        = {Sex specific expression of progesterone receptor in mouse lower urinary tract},
  url          = {http://dx.doi.org/10.1016/j.mce.2004.11.008},
  volume       = {230},
  year         = {2005},
}