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Vasodilation effect of atropine on rat mesenteric artery

Zheng, Jianpu LU ; Cao, Y X; Xu, Cang-Bao LU and Edvinsson, Lars LU (2005) In Yao Xue Xue Bao 40(5). p.402-405
Abstract
AIM: To study the vasodilation effect of atropine and its mechanism. METHODS: Isometric tension was recorded in isolated rat super mesenteric arteries precontracted by noradrenaline (NE) to study the vasodilation effect of atropine, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation. RESULTS: Atropine was shown to significantly dilate the endothelium-intact and endothelium-denuded arteries precontracted by NE. Nomega-Nitro-L-arginine methyl ester (L-NAME, nitric oxide synthase inhabitor), indomethacin (cyclooxygenase inhibitor), propranolol (general beta adrenoceptor antagonist) and glibenclamide (ATP sensitive potassium channel inhibitor) showed no effect on vasodilation of atropine. Atropine... (More)
AIM: To study the vasodilation effect of atropine and its mechanism. METHODS: Isometric tension was recorded in isolated rat super mesenteric arteries precontracted by noradrenaline (NE) to study the vasodilation effect of atropine, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation. RESULTS: Atropine was shown to significantly dilate the endothelium-intact and endothelium-denuded arteries precontracted by NE. Nomega-Nitro-L-arginine methyl ester (L-NAME, nitric oxide synthase inhabitor), indomethacin (cyclooxygenase inhibitor), propranolol (general beta adrenoceptor antagonist) and glibenclamide (ATP sensitive potassium channel inhibitor) showed no effect on vasodilation of atropine. Atropine did not affect the concentration-contraction curve of K+. However, atropine suppressed the contraction induced by NE and CaCl2, but not that by caffeine in the Ca+ -free Krebs solution. CONCLUSION: Atropine showed significant vasodilation effect which may derive, in part, from endothelium. Besides, atropine could inhibit the receptor-mediated Ca2+ -influx and Ca2+ -release, which was inferred to the mechanism of atropine on vasodilation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Yao Xue Xue Bao
volume
40
issue
5
pages
402 - 405
publisher
Chinese Electronic Periodical Services
external identifiers
  • scopus:22244475403
ISSN
0513-4870
language
English
LU publication?
yes
id
85de6cc1-96db-44d3-830d-0d763f6efa5f (old id 1133934)
date added to LUP
2008-06-23 09:44:06
date last changed
2017-01-01 06:44:10
@article{85de6cc1-96db-44d3-830d-0d763f6efa5f,
  abstract     = {AIM: To study the vasodilation effect of atropine and its mechanism. METHODS: Isometric tension was recorded in isolated rat super mesenteric arteries precontracted by noradrenaline (NE) to study the vasodilation effect of atropine, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation. RESULTS: Atropine was shown to significantly dilate the endothelium-intact and endothelium-denuded arteries precontracted by NE. Nomega-Nitro-L-arginine methyl ester (L-NAME, nitric oxide synthase inhabitor), indomethacin (cyclooxygenase inhibitor), propranolol (general beta adrenoceptor antagonist) and glibenclamide (ATP sensitive potassium channel inhibitor) showed no effect on vasodilation of atropine. Atropine did not affect the concentration-contraction curve of K+. However, atropine suppressed the contraction induced by NE and CaCl2, but not that by caffeine in the Ca+ -free Krebs solution. CONCLUSION: Atropine showed significant vasodilation effect which may derive, in part, from endothelium. Besides, atropine could inhibit the receptor-mediated Ca2+ -influx and Ca2+ -release, which was inferred to the mechanism of atropine on vasodilation.},
  author       = {Zheng, Jianpu and Cao, Y X and Xu, Cang-Bao and Edvinsson, Lars},
  issn         = {0513-4870},
  language     = {eng},
  number       = {5},
  pages        = {402--405},
  publisher    = {Chinese Electronic Periodical Services},
  series       = {Yao Xue Xue Bao},
  title        = {Vasodilation effect of atropine on rat mesenteric artery},
  volume       = {40},
  year         = {2005},
}