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Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro

Khairul, Mohd Fadzli Mustaffa ; Tan Grahn, Hooi Min LU ; Low, Jen Hou ; Nasriyyah, Che Husin Che ; A'shikin, Azahri Noor ; Norazmi, Mohd Nor ; Ravichandran, Manickam and Raju, Suraparaju Sivachandra (2006) In Japanese Journal of Infectious Diseases 59(5). p.329-331
Abstract
Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously. Isobolograms indicated that CQ-FLX combinations are more synergistic (mean fractional inhibitory concentration [FIC] index 0.55) than MQ-FLX (mean FIC index 0.64), and their synergistic effect was better than or at par with CQ-VPL (mean FIC index 0.88) and MQ-VPL (mean FIC... (More)
Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously. Isobolograms indicated that CQ-FLX combinations are more synergistic (mean fractional inhibitory concentration [FIC] index 0.55) than MQ-FLX (mean FIC index 0.64), and their synergistic effect was better than or at par with CQ-VPL (mean FIC index 0.88) and MQ-VPL (mean FIC index 0.60) combinations. We conclude that the FLX potentiates the CQ and MQ response on multidrug-resistant P. falciparum at clinically achievable concentrations. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Japanese Journal of Infectious Diseases
volume
59
issue
5
pages
329 - 331
publisher
National Institute of Infectious Diseases. (Tokyo)
external identifiers
  • pmid:17060702
  • scopus:33750487144
ISSN
1344-6304
language
English
LU publication?
yes
id
480ffe81-1cda-4547-864f-3c18d16d2a9b (old id 1135905)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/17060702
http://www.nih.go.jp/JJID/59/329.pdf
date added to LUP
2016-04-01 17:03:01
date last changed
2020-01-12 20:00:06
@article{480ffe81-1cda-4547-864f-3c18d16d2a9b,
  abstract     = {Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously. Isobolograms indicated that CQ-FLX combinations are more synergistic (mean fractional inhibitory concentration [FIC] index 0.55) than MQ-FLX (mean FIC index 0.64), and their synergistic effect was better than or at par with CQ-VPL (mean FIC index 0.88) and MQ-VPL (mean FIC index 0.60) combinations. We conclude that the FLX potentiates the CQ and MQ response on multidrug-resistant P. falciparum at clinically achievable concentrations.},
  author       = {Khairul, Mohd Fadzli Mustaffa and Tan Grahn, Hooi Min and Low, Jen Hou and Nasriyyah, Che Husin Che and A'shikin, Azahri Noor and Norazmi, Mohd Nor and Ravichandran, Manickam and Raju, Suraparaju Sivachandra},
  issn         = {1344-6304},
  language     = {eng},
  number       = {5},
  pages        = {329--331},
  publisher    = {National Institute of Infectious Diseases. (Tokyo)},
  series       = {Japanese Journal of Infectious Diseases},
  title        = {Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro},
  url          = {http://www.ncbi.nlm.nih.gov/pubmed/17060702},
  volume       = {59},
  year         = {2006},
}