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Bacillus Calmette-Guerin vaccination and infant mortality

Roth, Adam LU ; Garly, M L ; Jensen, H ; Nielsen, J and Aaby, P (2006) In Expert Review of Vaccines 5(2). p.277-293
Abstract
When the bacillus Calmette-Guerin (BCG) vaccine was introduced in the 1920s, it was suggested that BCG occasionally had nonspecific beneficial effects on mortality beyond the specific protection against tuberculosis. Considering that BCG has since then become the most used vaccine in the world, surprisingly few studies have been undertaken into the effect of BCG on general mortality and morbidity. Recent studies suggest that BCG has beneficial nontargeted effects on general infant morbidity and mortality in low-income countries, often with the most pronounced effect among girls. These observational findings are supported by early trials in which children were randomized or alternated to BCG vaccination. Furthermore, a BCG scar and a... (More)
When the bacillus Calmette-Guerin (BCG) vaccine was introduced in the 1920s, it was suggested that BCG occasionally had nonspecific beneficial effects on mortality beyond the specific protection against tuberculosis. Considering that BCG has since then become the most used vaccine in the world, surprisingly few studies have been undertaken into the effect of BCG on general mortality and morbidity. Recent studies suggest that BCG has beneficial nontargeted effects on general infant morbidity and mortality in low-income countries, often with the most pronounced effect among girls. These observational findings are supported by early trials in which children were randomized or alternated to BCG vaccination. Furthermore, a BCG scar and a positive tuberculin reaction are related to better survival among BCG-vaccinated children in low-income countries, especially for girls. The findings are not explained by frailty bias, in other words, that healthy children are more likely to receive BCG vaccination. A nonspecific, gender-differential effect of BCG on general infant mortality may have large implications for tuberculosis vaccine research and routine vaccination policy. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Expert Review of Vaccines
volume
5
issue
2
pages
277 - 293
publisher
Future Drugs Ltd
external identifiers
  • pmid:16608427
  • scopus:33746681876
  • pmid:16608427
ISSN
1744-8395
DOI
10.1586/14760584.5.2.277
language
English
LU publication?
yes
id
f3d38bf1-081d-4e13-9c9f-68adb771bf69 (old id 1136084)
date added to LUP
2016-04-01 12:30:41
date last changed
2020-12-27 05:55:19
@article{f3d38bf1-081d-4e13-9c9f-68adb771bf69,
  abstract     = {When the bacillus Calmette-Guerin (BCG) vaccine was introduced in the 1920s, it was suggested that BCG occasionally had nonspecific beneficial effects on mortality beyond the specific protection against tuberculosis. Considering that BCG has since then become the most used vaccine in the world, surprisingly few studies have been undertaken into the effect of BCG on general mortality and morbidity. Recent studies suggest that BCG has beneficial nontargeted effects on general infant morbidity and mortality in low-income countries, often with the most pronounced effect among girls. These observational findings are supported by early trials in which children were randomized or alternated to BCG vaccination. Furthermore, a BCG scar and a positive tuberculin reaction are related to better survival among BCG-vaccinated children in low-income countries, especially for girls. The findings are not explained by frailty bias, in other words, that healthy children are more likely to receive BCG vaccination. A nonspecific, gender-differential effect of BCG on general infant mortality may have large implications for tuberculosis vaccine research and routine vaccination policy.},
  author       = {Roth, Adam and Garly, M L and Jensen, H and Nielsen, J and Aaby, P},
  issn         = {1744-8395},
  language     = {eng},
  number       = {2},
  pages        = {277--293},
  publisher    = {Future Drugs Ltd},
  series       = {Expert Review of Vaccines},
  title        = {Bacillus Calmette-Guerin vaccination and infant mortality},
  url          = {http://dx.doi.org/10.1586/14760584.5.2.277},
  doi          = {10.1586/14760584.5.2.277},
  volume       = {5},
  year         = {2006},
}