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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

Bryder, David LU ; Rossi, Derrick J and Weissman, Irving L (2006) In American Journal of Pathology 169(2). p.338-346
Abstract
The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of... (More)
The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Pathology
volume
169
issue
2
pages
338 - 346
publisher
American Society for Investigative Pathology
external identifiers
  • pmid:16877336
  • scopus:33746617272
ISSN
1525-2191
DOI
10.2353/ajpath.2006.060312
language
English
LU publication?
yes
id
8e4f6808-4965-4664-9242-eb273a7bc4c4 (old id 1136090)
date added to LUP
2016-04-01 12:08:43
date last changed
2020-12-15 02:45:40
@article{8e4f6808-4965-4664-9242-eb273a7bc4c4,
  abstract     = {The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.},
  author       = {Bryder, David and Rossi, Derrick J and Weissman, Irving L},
  issn         = {1525-2191},
  language     = {eng},
  number       = {2},
  pages        = {338--346},
  publisher    = {American Society for Investigative Pathology},
  series       = {American Journal of Pathology},
  title        = {Hematopoietic stem cells: the paradigmatic tissue-specific stem cell},
  url          = {http://dx.doi.org/10.2353/ajpath.2006.060312},
  doi          = {10.2353/ajpath.2006.060312},
  volume       = {169},
  year         = {2006},
}