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Regulation of ornithine decarboxylase expression

Persson, Lo LU (2006) p.399-414
Abstract
It has become increasingly obvious during the last two decades that a multitude of cellular processes are highly dependent on adequate levels of polyamines (1–6). Too high concentrations of the polyamines are toxic to the cell and may induce cell death or apoptosis (7). On the other hand, too low concentrations may negatively affect anabolic events, such as the synthesis of DNA, RNA, and protein, eventually giving rise to cellgrowth arrest (6). Thus it is important for cells to maintain their polyamine concentrations within rather narrow limits. Polyamine homeostasis is achieved by a careful balance between synthesis, degradation, and uptake of the amines (3). The introduction of molecular techniques in studies concerning polyamine... (More)
It has become increasingly obvious during the last two decades that a multitude of cellular processes are highly dependent on adequate levels of polyamines (1–6). Too high concentrations of the polyamines are toxic to the cell and may induce cell death or apoptosis (7). On the other hand, too low concentrations may negatively affect anabolic events, such as the synthesis of DNA, RNA, and protein, eventually giving rise to cellgrowth arrest (6). Thus it is important for cells to maintain their polyamine concentrations within rather narrow limits. Polyamine homeostasis is achieved by a careful balance between synthesis, degradation, and uptake of the amines (3). The introduction of molecular techniques in studies concerning polyamine metabolism has revealed a complex network of regulatory mechanisms involved in the cellular control of polyamine levels. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Polyamine Cell signaling: Physiology, Pharmacology, and Cancer Research
editor
Wang, J-Y and Casero, R A
pages
399 - 414
publisher
Humana Press
external identifiers
  • scopus:42449107911
ISBN
978-1-58829-625-2
DOI
10.1007/978-1-59745-145-1
language
English
LU publication?
yes
id
dd7b8e0b-b9fb-433b-9374-86b56cc116b0 (old id 1136244)
date added to LUP
2016-04-04 10:38:48
date last changed
2020-12-08 02:23:37
@inbook{dd7b8e0b-b9fb-433b-9374-86b56cc116b0,
  abstract     = {It has become increasingly obvious during the last two decades that a multitude of cellular processes are highly dependent on adequate levels of polyamines (1–6). Too high concentrations of the polyamines are toxic to the cell and may induce cell death or apoptosis (7). On the other hand, too low concentrations may negatively affect anabolic events, such as the synthesis of DNA, RNA, and protein, eventually giving rise to cellgrowth arrest (6). Thus it is important for cells to maintain their polyamine concentrations within rather narrow limits. Polyamine homeostasis is achieved by a careful balance between synthesis, degradation, and uptake of the amines (3). The introduction of molecular techniques in studies concerning polyamine metabolism has revealed a complex network of regulatory mechanisms involved in the cellular control of polyamine levels.},
  author       = {Persson, Lo},
  booktitle    = {Polyamine Cell signaling: Physiology, Pharmacology, and Cancer Research},
  editor       = {Wang, J-Y and Casero, R A},
  isbn         = {978-1-58829-625-2},
  language     = {eng},
  pages        = {399--414},
  publisher    = {Humana Press},
  title        = {Regulation of ornithine decarboxylase expression},
  url          = {http://dx.doi.org/10.1007/978-1-59745-145-1},
  doi          = {10.1007/978-1-59745-145-1},
  year         = {2006},
}