Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
Gebe, John A ; Unrath, Kellee A ; Falk, Ben A ; Kouichi, Ito ; Wen, Li ; Daniels, Terri L ; Lernmark, Åke LU
and Nepom, Gerald T
(2006)
In Clinical Immunology
121(3).
p.294-304
- Abstract
- We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1*0404 HLA transgenic mice. Diabetic and older non-diabetic mice exhibited a proliferative response to an immunodominant epitope from GAD65 (555-567) and also from GFAP (240-252) but not from an immunogenic epitope from diabetes-associated islet-specific glucose-6-phosphatase catalytic subunit-related protein. The response to both of these self-antigens is not observed in young mice but is observed in older non-diabetic mice and is accompanied by histological evidence of insulitis in... (More)
- We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1*0404 HLA transgenic mice. Diabetic and older non-diabetic mice exhibited a proliferative response to an immunodominant epitope from GAD65 (555-567) and also from GFAP (240-252) but not from an immunogenic epitope from diabetes-associated islet-specific glucose-6-phosphatase catalytic subunit-related protein. The response to both of these self-antigens is not observed in young mice but is observed in older non-diabetic mice and is accompanied by histological evidence of insulitis in the absence of overt diabetes. Islet infiltrates in older non-diabetic mice and diabetic mice contain CD4(+)/FoxP3(+) cells and suggest the presence of a regulatory mechanism prior and during diabetic disease. Diabetes penetrance in RIP-B7/DR0404 mice (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1136259
- author
- Gebe, John A
; Unrath, Kellee A
; Falk, Ben A
; Kouichi, Ito
; Wen, Li
; Daniels, Terri L
; Lernmark, Åke
LU
and Nepom, Gerald T
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes, Tolerance, MHC, T cells, Transgenic
- in
- Clinical Immunology
- volume
- 121
- issue
- 3
- pages
- 294 - 304
- publisher
- Elsevier
- external identifiers
-
- scopus:33750959226
- ISSN
- 1521-6616
- DOI
- 10.1016/j.clim.2006.08.002
- language
- English
- LU publication?
- yes
- id
- 5f3b5a9d-d7b1-43a5-a845-9ac2fa301793 (old id 1136259)
- date added to LUP
- 2016-04-01 12:03:05
- date last changed
- 2022-01-26 22:07:20
@article{5f3b5a9d-d7b1-43a5-a845-9ac2fa301793,
abstract = {{We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated antigens glutamic acid decarboxylase (GAD65) and glial fibrillary acidic protein (GFAP) in RIP-B7/DRB1*0404 HLA transgenic mice. Diabetic and older non-diabetic mice exhibited a proliferative response to an immunodominant epitope from GAD65 (555-567) and also from GFAP (240-252) but not from an immunogenic epitope from diabetes-associated islet-specific glucose-6-phosphatase catalytic subunit-related protein. The response to both of these self-antigens is not observed in young mice but is observed in older non-diabetic mice and is accompanied by histological evidence of insulitis in the absence of overt diabetes. Islet infiltrates in older non-diabetic mice and diabetic mice contain CD4(+)/FoxP3(+) cells and suggest the presence of a regulatory mechanism prior and during diabetic disease. Diabetes penetrance in RIP-B7/DR0404 mice}},
author = {{Gebe, John A and Unrath, Kellee A and Falk, Ben A and Kouichi, Ito and Wen, Li and Daniels, Terri L and Lernmark, Åke and Nepom, Gerald T}},
issn = {{1521-6616}},
keywords = {{Diabetes; Tolerance; MHC; T cells; Transgenic}},
language = {{eng}},
number = {{3}},
pages = {{294--304}},
publisher = {{Elsevier}},
series = {{Clinical Immunology}},
title = {{Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.}},
url = {{http://dx.doi.org/10.1016/j.clim.2006.08.002}},
doi = {{10.1016/j.clim.2006.08.002}},
volume = {{121}},
year = {{2006}},
}