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Focus on the tumor periphery in MRI evaluation of soft tissue sarcoma: infiltrative growth signifies poor prognosis

Fernebro, Josefin LU ; Wiklund, Marie ; Jonsson, Kjell LU ; Rydholm, Anders LU ; Nilbert, Mef LU ; Bendahl, Pär-Ola LU and Engellau, Jacob LU (2006) In Sarcoma 2006. p.21251-21251
Abstract
Purpose. Infiltrative microscopical peripheral growth of soft tissue sarcomas (STS) has been shown to be of prognostic importance and preoperative risk stratification could individualize neoadjuvant treatment. Patients and methods. We assessed peripheral tumour growth pattern on preoperative MRI from 78 STS. The findings were correlated to histopathology and to outcome. Results. The MRI-based peripheral tumour growth pattern was classified as pushing in 34 tumours, focally infiltrative in 25, and diffusely infiltrative in 19. All tumours with diffuse infiltration on MRI also showed microscopical infiltration, whereas MRI failed to identify infiltration in two-thirds of the microscopically infiltrative tumours. Diffusely infiltrative growth... (More)
Purpose. Infiltrative microscopical peripheral growth of soft tissue sarcomas (STS) has been shown to be of prognostic importance and preoperative risk stratification could individualize neoadjuvant treatment. Patients and methods. We assessed peripheral tumour growth pattern on preoperative MRI from 78 STS. The findings were correlated to histopathology and to outcome. Results. The MRI-based peripheral tumour growth pattern was classified as pushing in 34 tumours, focally infiltrative in 25, and diffusely infiltrative in 19. All tumours with diffuse infiltration on MRI also showed microscopical infiltration, whereas MRI failed to identify infiltration in two-thirds of the microscopically infiltrative tumours. Diffusely infiltrative growth on MRI gave a 2.5 times increased risk of metastases (P = .01) and a 3.7 times higher risk of local recurrence (P = .02). Discussion. Based on this observation we suggest that MRI evaluation of STS should focus on the peripheral tumour growth pattern since it adds prognostic information of value for decisions on neoadjuvant therapies. (Less)
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type
Contribution to journal
publication status
published
subject
in
Sarcoma
volume
2006
pages
21251 - 21251
publisher
Hindawi Limited
external identifiers
  • scopus:33845879069
ISSN
1357-714X
DOI
10.1155/SRCM/2006/21251
language
English
LU publication?
yes
id
d02b202c-99e7-4b09-a740-e184339ffda6 (old id 1137014)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17496992&dopt=Abstract
date added to LUP
2016-04-01 16:26:36
date last changed
2021-10-06 03:36:01
@article{d02b202c-99e7-4b09-a740-e184339ffda6,
  abstract     = {Purpose. Infiltrative microscopical peripheral growth of soft tissue sarcomas (STS) has been shown to be of prognostic importance and preoperative risk stratification could individualize neoadjuvant treatment. Patients and methods. We assessed peripheral tumour growth pattern on preoperative MRI from 78 STS. The findings were correlated to histopathology and to outcome. Results. The MRI-based peripheral tumour growth pattern was classified as pushing in 34 tumours, focally infiltrative in 25, and diffusely infiltrative in 19. All tumours with diffuse infiltration on MRI also showed microscopical infiltration, whereas MRI failed to identify infiltration in two-thirds of the microscopically infiltrative tumours. Diffusely infiltrative growth on MRI gave a 2.5 times increased risk of metastases (P = .01) and a 3.7 times higher risk of local recurrence (P = .02). Discussion. Based on this observation we suggest that MRI evaluation of STS should focus on the peripheral tumour growth pattern since it adds prognostic information of value for decisions on neoadjuvant therapies.},
  author       = {Fernebro, Josefin and Wiklund, Marie and Jonsson, Kjell and Rydholm, Anders and Nilbert, Mef and Bendahl, Pär-Ola and Engellau, Jacob},
  issn         = {1357-714X},
  language     = {eng},
  pages        = {21251--21251},
  publisher    = {Hindawi Limited},
  series       = {Sarcoma},
  title        = {Focus on the tumor periphery in MRI evaluation of soft tissue sarcoma: infiltrative growth signifies poor prognosis},
  url          = {http://dx.doi.org/10.1155/SRCM/2006/21251},
  doi          = {10.1155/SRCM/2006/21251},
  volume       = {2006},
  year         = {2006},
}