A new understanding of pancreatitis-associated pulmonary injury
(2006) In Journal of Organ Dysfuntion 2(3). p.156-165- Abstract
- Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-agr and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit... (More)
- Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-agr and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit different expression and activation patterns in the development of PALI. Mast cells seem to be involved in the initiation of leukocyte activation during the initial phase of PALI. Activation of the protein kinase C (PKC) signaling pathway could play an important role in the pathogenesis of PALI. Inhibition of PKC may be one candidate to prevent and treat the development of PALI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1137135
- author
- Zhao, Xia LU ; Shi, Changbin LU ; Wang, Xiangdong LU and Andersson, Roland LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adhesion molecules, mast cells, acute respiratory distress syndrome, Acute pancreatitis, lung injury, protein kinase C
- in
- Journal of Organ Dysfuntion
- volume
- 2
- issue
- 3
- pages
- 156 - 165
- publisher
- Informa Healthcare
- external identifiers
-
- scopus:33748455055
- ISSN
- 1747-1060
- DOI
- 10.1080/17471060600799520
- language
- English
- LU publication?
- yes
- id
- 5b68563e-eef6-44a0-b0e3-f4ce67630f15 (old id 1137135)
- date added to LUP
- 2016-04-01 12:19:26
- date last changed
- 2022-01-27 02:01:47
@article{5b68563e-eef6-44a0-b0e3-f4ce67630f15, abstract = {{Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-agr and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit different expression and activation patterns in the development of PALI. Mast cells seem to be involved in the initiation of leukocyte activation during the initial phase of PALI. Activation of the protein kinase C (PKC) signaling pathway could play an important role in the pathogenesis of PALI. Inhibition of PKC may be one candidate to prevent and treat the development of PALI.}}, author = {{Zhao, Xia and Shi, Changbin and Wang, Xiangdong and Andersson, Roland}}, issn = {{1747-1060}}, keywords = {{adhesion molecules; mast cells; acute respiratory distress syndrome; Acute pancreatitis; lung injury; protein kinase C}}, language = {{eng}}, number = {{3}}, pages = {{156--165}}, publisher = {{Informa Healthcare}}, series = {{Journal of Organ Dysfuntion}}, title = {{A new understanding of pancreatitis-associated pulmonary injury}}, url = {{http://dx.doi.org/10.1080/17471060600799520}}, doi = {{10.1080/17471060600799520}}, volume = {{2}}, year = {{2006}}, }