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Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models

Holmquist Mengelbier, Linda LU ; Löfstedt, Tobias LU and Påhlman, Sven LU (2006) 587. p.179-193
Abstract
The tumor oxygenation status associates with aggressive behavior. Oxygen shortage, hypoxia, is a major driving force behind tumor vascularization, and hypoxia enhances mutational rate, metastatic spread, and resistance to radiation and chemotherapy. We recently discovered that hypoxia promotes dedifferentiation of neuroblastoma and breast carcinoma cells and development of stem cell-like features. In both these tumor forms there is a correlation between low differentiation stage and poor outcome, and we conclude that the dedifferentiating effect of lowered oxygen adds to the aggressive phenotype induced by hypoxia. With neuroblastoma and breast carcinoma as human tumor model systems, we have addressed questions related to hypoxia-induced... (More)
The tumor oxygenation status associates with aggressive behavior. Oxygen shortage, hypoxia, is a major driving force behind tumor vascularization, and hypoxia enhances mutational rate, metastatic spread, and resistance to radiation and chemotherapy. We recently discovered that hypoxia promotes dedifferentiation of neuroblastoma and breast carcinoma cells and development of stem cell-like features. In both these tumor forms there is a correlation between low differentiation stage and poor outcome, and we conclude that the dedifferentiating effect of lowered oxygen adds to the aggressive phenotype induced by hypoxia. With neuroblastoma and breast carcinoma as human tumor model systems, we have addressed questions related to hypoxia-induced molecular mechanisms governing malignant behavior of tumor cells, with emphasis on differentiation and growth control. By global gene expression analyses we are currently screening for gene products exclusively expressed or modified in hypoxic cells with the aim to use them as targets for treatment. (Less)
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author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Animals, Anoxia, Breast Neoplasms, Cell Differentiation, Gene Expression Regulation, Neoplastic, Humans, Neuroblastoma, Phenotype
host publication
Advances in experimental medicine and biology
volume
587
pages
179 - 193
publisher
Springer
external identifiers
  • pmid:17163166
  • wos:000243248800016
  • scopus:33947164399
ISSN
0065-2598
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200)
id
d23eb6be-2289-4026-bd45-33a8e3b70cf1 (old id 1137191)
date added to LUP
2016-04-01 16:54:23
date last changed
2020-02-26 05:10:44
@inproceedings{d23eb6be-2289-4026-bd45-33a8e3b70cf1,
  abstract     = {The tumor oxygenation status associates with aggressive behavior. Oxygen shortage, hypoxia, is a major driving force behind tumor vascularization, and hypoxia enhances mutational rate, metastatic spread, and resistance to radiation and chemotherapy. We recently discovered that hypoxia promotes dedifferentiation of neuroblastoma and breast carcinoma cells and development of stem cell-like features. In both these tumor forms there is a correlation between low differentiation stage and poor outcome, and we conclude that the dedifferentiating effect of lowered oxygen adds to the aggressive phenotype induced by hypoxia. With neuroblastoma and breast carcinoma as human tumor model systems, we have addressed questions related to hypoxia-induced molecular mechanisms governing malignant behavior of tumor cells, with emphasis on differentiation and growth control. By global gene expression analyses we are currently screening for gene products exclusively expressed or modified in hypoxic cells with the aim to use them as targets for treatment.},
  author       = {Holmquist Mengelbier, Linda and Löfstedt, Tobias and Påhlman, Sven},
  booktitle    = {Advances in experimental medicine and biology},
  issn         = {0065-2598},
  language     = {eng},
  pages        = {179--193},
  publisher    = {Springer},
  title        = {Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models},
  volume       = {587},
  year         = {2006},
}