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A new and evolving paradigm for biocompatibility

Hilborn, Jöns and Bjursten, Lars Magnus LU (2007) In Journal of Tissue Engineering and Regenerative Medicine 1(2). p.110-119
Abstract
We propose that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response and the performance of the device. The interfacial mechanics depends on several different factors related to the physical shape of the device and its surface as well as properties of the host tissue and the loading conditions of the device and surrounding tissue. It seems plausible that the growth of the fibrotic tissue to support mechanical loads is governed by the same priniciples as depicted by Wolfs' Law for bone. Of course, biocompatibility will have different implications depending on which vantage point we look at the host-material interface. Another implication is that only limited aspects of... (More)
We propose that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response and the performance of the device. The interfacial mechanics depends on several different factors related to the physical shape of the device and its surface as well as properties of the host tissue and the loading conditions of the device and surrounding tissue. It seems plausible that the growth of the fibrotic tissue to support mechanical loads is governed by the same priniciples as depicted by Wolfs' Law for bone. Of course, biocompatibility will have different implications depending on which vantage point we look at the host-material interface. Another implication is that only limited aspects of biocompatibility is measurable with current in vitro tests and that the elicited host response in vivo models remains crucial for evaluation of medical devices and tissue engineering constructs. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biocompatibility, mechanical stress, interfacial mechanics, macrophage, Young's modulus, surface texture
in
Journal of Tissue Engineering and Regenerative Medicine
volume
1
issue
2
pages
110 - 119
publisher
John Wiley & Sons
external identifiers
  • wos:000256519600003
  • scopus:40949125750
ISSN
1932-6254
DOI
10.1002/term.4
language
English
LU publication?
yes
id
c679c123-95aa-45ff-9203-326968ce9cca (old id 1138344)
date added to LUP
2008-08-19 11:13:30
date last changed
2017-10-01 03:55:48
@article{c679c123-95aa-45ff-9203-326968ce9cca,
  abstract     = {We propose that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response and the performance of the device. The interfacial mechanics depends on several different factors related to the physical shape of the device and its surface as well as properties of the host tissue and the loading conditions of the device and surrounding tissue. It seems plausible that the growth of the fibrotic tissue to support mechanical loads is governed by the same priniciples as depicted by Wolfs' Law for bone. Of course, biocompatibility will have different implications depending on which vantage point we look at the host-material interface. Another implication is that only limited aspects of biocompatibility is measurable with current in vitro tests and that the elicited host response in vivo models remains crucial for evaluation of medical devices and tissue engineering constructs.},
  author       = {Hilborn, Jöns and Bjursten, Lars Magnus},
  issn         = {1932-6254},
  keyword      = {biocompatibility,mechanical stress,interfacial mechanics,macrophage,Young's modulus,surface texture},
  language     = {eng},
  number       = {2},
  pages        = {110--119},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Tissue Engineering and Regenerative Medicine},
  title        = {A new and evolving paradigm for biocompatibility},
  url          = {http://dx.doi.org/10.1002/term.4},
  volume       = {1},
  year         = {2007},
}