A new and evolving paradigm for biocompatibility
(2007) In Journal of Tissue Engineering and Regenerative Medicine 1(2). p.110-119- Abstract
- We propose that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response and the performance of the device. The interfacial mechanics depends on several different factors related to the physical shape of the device and its surface as well as properties of the host tissue and the loading conditions of the device and surrounding tissue. It seems plausible that the growth of the fibrotic tissue to support mechanical loads is governed by the same priniciples as depicted by Wolfs' Law for bone. Of course, biocompatibility will have different implications depending on which vantage point we look at the host-material interface. Another implication is that only limited aspects of... (More)
- We propose that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response and the performance of the device. The interfacial mechanics depends on several different factors related to the physical shape of the device and its surface as well as properties of the host tissue and the loading conditions of the device and surrounding tissue. It seems plausible that the growth of the fibrotic tissue to support mechanical loads is governed by the same priniciples as depicted by Wolfs' Law for bone. Of course, biocompatibility will have different implications depending on which vantage point we look at the host-material interface. Another implication is that only limited aspects of biocompatibility is measurable with current in vitro tests and that the elicited host response in vivo models remains crucial for evaluation of medical devices and tissue engineering constructs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1138344
- author
- Hilborn, Jöns and Bjursten, Lars Magnus LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biocompatibility, mechanical stress, interfacial mechanics, macrophage, Young's modulus, surface texture
- in
- Journal of Tissue Engineering and Regenerative Medicine
- volume
- 1
- issue
- 2
- pages
- 110 - 119
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000256519600003
- scopus:40949125750
- ISSN
- 1932-6254
- DOI
- 10.1002/term.4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)
- id
- c679c123-95aa-45ff-9203-326968ce9cca (old id 1138344)
- date added to LUP
- 2016-04-01 12:28:45
- date last changed
- 2022-03-29 01:24:30
@article{c679c123-95aa-45ff-9203-326968ce9cca,
abstract = {{We propose that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response and the performance of the device. The interfacial mechanics depends on several different factors related to the physical shape of the device and its surface as well as properties of the host tissue and the loading conditions of the device and surrounding tissue. It seems plausible that the growth of the fibrotic tissue to support mechanical loads is governed by the same priniciples as depicted by Wolfs' Law for bone. Of course, biocompatibility will have different implications depending on which vantage point we look at the host-material interface. Another implication is that only limited aspects of biocompatibility is measurable with current in vitro tests and that the elicited host response in vivo models remains crucial for evaluation of medical devices and tissue engineering constructs.}},
author = {{Hilborn, Jöns and Bjursten, Lars Magnus}},
issn = {{1932-6254}},
keywords = {{biocompatibility; mechanical stress; interfacial mechanics; macrophage; Young's modulus; surface texture}},
language = {{eng}},
number = {{2}},
pages = {{110--119}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Tissue Engineering and Regenerative Medicine}},
title = {{A new and evolving paradigm for biocompatibility}},
url = {{http://dx.doi.org/10.1002/term.4}},
doi = {{10.1002/term.4}},
volume = {{1}},
year = {{2007}},
}