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Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon

Salehi, S Albert LU ; Qader, Saleem LU ; Grapengiesser, Eva and Hellman, Bo (2007) In Regulatory Peptides 144(1-3). p.43-49
Abstract
It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift... (More)
It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift 2.4+/-0.2 min), supporting the idea that the delta-cells have a local inhibitory effect on glucagon release. It was possible to remove the pulses of somatostatin and glucagon with maintenance of the insulin rhythmicity by addition of 1 mumol/l of the P2Y(1) receptor antagonist MRS 2179. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pancreas perfusion, MRS 2179, Somatostatin pulse, Purinoceptor
in
Regulatory Peptides
volume
144
issue
1-3
pages
43 - 49
publisher
Elsevier
external identifiers
  • pmid:17628719
  • wos:000251601800007
  • scopus:35648972696
ISSN
1873-1686
DOI
10.1016/j.regpep.2007.06.003
language
English
LU publication?
yes
id
993bf119-7084-4b61-ad75-a895c2a0ab5b (old id 1138378)
date added to LUP
2008-08-19 11:32:12
date last changed
2017-01-01 04:41:54
@article{993bf119-7084-4b61-ad75-a895c2a0ab5b,
  abstract     = {It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift 2.4+/-0.2 min), supporting the idea that the delta-cells have a local inhibitory effect on glucagon release. It was possible to remove the pulses of somatostatin and glucagon with maintenance of the insulin rhythmicity by addition of 1 mumol/l of the P2Y(1) receptor antagonist MRS 2179.},
  author       = {Salehi, S Albert and Qader, Saleem and Grapengiesser, Eva and Hellman, Bo},
  issn         = {1873-1686},
  keyword      = {Pancreas perfusion,MRS 2179,Somatostatin pulse,Purinoceptor},
  language     = {eng},
  number       = {1-3},
  pages        = {43--49},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon},
  url          = {http://dx.doi.org/10.1016/j.regpep.2007.06.003},
  volume       = {144},
  year         = {2007},
}