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Rapid decline of persistent organochlorine pollutants in serum among young Swedish males

Axmon, Anna LU ; Hagmar, Lars and Jönsson, Bo A LU (2008) In Chemosphere 70(9). p.1620-1628
Abstract
To investigate a possible time trend in serum concentrations of persistent organochlorine pollutants (POPs), representative samples of the young (median age 18 years) Swedish male population were investigated in the years 2000 and 2004. Due to their low age, these men were assumed not to have reached steady state of body burdens of POPs, why their serum concentrations were considered to represent ongoing dietary exposure. Serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethylene (p,p'-DDE), two biomarkers of exposure to POPs, were available for 274 and 223 men, respectively, in 2000 and for 200 men in 2004. The percentage of men with CB-153 or p,p'-DDE below the limit of detection... (More)
To investigate a possible time trend in serum concentrations of persistent organochlorine pollutants (POPs), representative samples of the young (median age 18 years) Swedish male population were investigated in the years 2000 and 2004. Due to their low age, these men were assumed not to have reached steady state of body burdens of POPs, why their serum concentrations were considered to represent ongoing dietary exposure. Serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethylene (p,p'-DDE), two biomarkers of exposure to POPs, were available for 274 and 223 men, respectively, in 2000 and for 200 men in 2004. The percentage of men with CB-153 or p,p'-DDE below the limit of detection (LOD) was significantly higher in 2004 than in 2000 (30% vs. none, p < 0.001 for CB-153 and 65% vs. 6%, p < 0.001 for p,p'-DDE). Moreover, the median serum concentration of CB-153 decreased from 66ngg(-1) lipid to 19ngg(-1), corresponding to a yearly decrease of about 26%. The analogous analysis was not done for p,p'-DDE since the median serum concentration in 2004 was below the LOD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Environmental pollutants, Biomarkers, Persistent organochlorine pollutants, Cross-sectional study
in
Chemosphere
volume
70
issue
9
pages
1620 - 1628
publisher
Elsevier
external identifiers
  • pmid:17845816
  • wos:000253180300011
  • scopus:38349080671
ISSN
1879-1298
DOI
10.1016/j.chemosphere.2007.07.077
language
English
LU publication?
yes
id
42e77594-7fcc-40b5-9c2e-8a4f99677e05 (old id 1139144)
date added to LUP
2008-04-29 10:05:47
date last changed
2017-03-12 03:25:06
@article{42e77594-7fcc-40b5-9c2e-8a4f99677e05,
  abstract     = {To investigate a possible time trend in serum concentrations of persistent organochlorine pollutants (POPs), representative samples of the young (median age 18 years) Swedish male population were investigated in the years 2000 and 2004. Due to their low age, these men were assumed not to have reached steady state of body burdens of POPs, why their serum concentrations were considered to represent ongoing dietary exposure. Serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethylene (p,p'-DDE), two biomarkers of exposure to POPs, were available for 274 and 223 men, respectively, in 2000 and for 200 men in 2004. The percentage of men with CB-153 or p,p'-DDE below the limit of detection (LOD) was significantly higher in 2004 than in 2000 (30% vs. none, p &lt; 0.001 for CB-153 and 65% vs. 6%, p &lt; 0.001 for p,p'-DDE). Moreover, the median serum concentration of CB-153 decreased from 66ngg(-1) lipid to 19ngg(-1), corresponding to a yearly decrease of about 26%. The analogous analysis was not done for p,p'-DDE since the median serum concentration in 2004 was below the LOD.},
  author       = {Axmon, Anna and Hagmar, Lars and Jönsson, Bo A},
  issn         = {1879-1298},
  keyword      = {Environmental pollutants,Biomarkers,Persistent organochlorine pollutants,Cross-sectional study},
  language     = {eng},
  number       = {9},
  pages        = {1620--1628},
  publisher    = {Elsevier},
  series       = {Chemosphere},
  title        = {Rapid decline of persistent organochlorine pollutants in serum among young Swedish males},
  url          = {http://dx.doi.org/10.1016/j.chemosphere.2007.07.077},
  volume       = {70},
  year         = {2008},
}