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Nasal neutrophil activity and mucinous secretory responsiveness in COPD.

Nihlén, Ulf LU ; Andersson, Morgan LU ; Löfdahl, Claes-Göran LU ; Persson, Carl LU ; Montnemery, Peter LU and Greiff, Lennart LU (2003) In Clinical Physiology and Functional Imaging2002-01-01+01:00 23(3). p.138-142
Abstract
Patients with chronic obstructive pulmonary disease (COPD) frequently report nasal symptoms. In the present study, we have examined whether or not COPD is associated with any nasal inflammation. Plasma exudation evoked by histamine challenges has been employed to improve the recovery of inflammatory indices in nasal lavage fluids. In 23 COPD-patients and 26 healthy subjects, all without history or signs of allergic rhinitis, nasal polyposis, or chronic rhinosinusitis, nasal saline-lavages were performed with and without histamine. alpha2-Macroglobulin, fucose, eosinophil cationic protein (ECP) and myeloperoxidase (MPO) were determined as indices of plasma exudation, mucinous secretion, eosinophil activity and neutrophil activity,... (More)
Patients with chronic obstructive pulmonary disease (COPD) frequently report nasal symptoms. In the present study, we have examined whether or not COPD is associated with any nasal inflammation. Plasma exudation evoked by histamine challenges has been employed to improve the recovery of inflammatory indices in nasal lavage fluids. In 23 COPD-patients and 26 healthy subjects, all without history or signs of allergic rhinitis, nasal polyposis, or chronic rhinosinusitis, nasal saline-lavages were performed with and without histamine. alpha2-Macroglobulin, fucose, eosinophil cationic protein (ECP) and myeloperoxidase (MPO) were determined as indices of plasma exudation, mucinous secretion, eosinophil activity and neutrophil activity, respectively. The difference in MPO-levels between the histamine and the saline lavage was greater in COPD patients compared with healthy subjects (P<0·05). Also, COPD patients reporting nasal symptoms presented an increase in MPO at histamine challenge (P<0·05, cf. saline) and greater differences in MPO and fucose, respectively, between the histamine and the saline lavage (P<0·05, cf. patients without symptoms). We conclude that COPD is not associated with any marked nasal inflammation. However, our observation on increased MPO-levels at histamine challenge suggests some degree of increased neutrophil activity in this condition. Furthermore, when associated with nasal symptoms, COPD may be associated with an increased nasal secretory responsiveness. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
23
issue
3
pages
138 - 142
publisher
Wiley Online Library
external identifiers
  • wos:000182774700004
  • scopus:0038628872
ISSN
1475-0961
DOI
10.1046/j.1475-097X.2003.00484.x
language
English
LU publication?
yes
id
357e9654-5f9a-496a-940c-42fbcce096e3 (old id 113918)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12752555&dopt=Abstract
date added to LUP
2007-07-02 14:34:04
date last changed
2018-05-29 11:34:04
@article{357e9654-5f9a-496a-940c-42fbcce096e3,
  abstract     = {Patients with chronic obstructive pulmonary disease (COPD) frequently report nasal symptoms. In the present study, we have examined whether or not COPD is associated with any nasal inflammation. Plasma exudation evoked by histamine challenges has been employed to improve the recovery of inflammatory indices in nasal lavage fluids. In 23 COPD-patients and 26 healthy subjects, all without history or signs of allergic rhinitis, nasal polyposis, or chronic rhinosinusitis, nasal saline-lavages were performed with and without histamine. alpha2-Macroglobulin, fucose, eosinophil cationic protein (ECP) and myeloperoxidase (MPO) were determined as indices of plasma exudation, mucinous secretion, eosinophil activity and neutrophil activity, respectively. The difference in MPO-levels between the histamine and the saline lavage was greater in COPD patients compared with healthy subjects (P&lt;0·05). Also, COPD patients reporting nasal symptoms presented an increase in MPO at histamine challenge (P&lt;0·05, cf. saline) and greater differences in MPO and fucose, respectively, between the histamine and the saline lavage (P&lt;0·05, cf. patients without symptoms). We conclude that COPD is not associated with any marked nasal inflammation. However, our observation on increased MPO-levels at histamine challenge suggests some degree of increased neutrophil activity in this condition. Furthermore, when associated with nasal symptoms, COPD may be associated with an increased nasal secretory responsiveness.},
  author       = {Nihlén, Ulf and Andersson, Morgan and Löfdahl, Claes-Göran and Persson, Carl and Montnemery, Peter and Greiff, Lennart},
  issn         = {1475-0961},
  language     = {eng},
  number       = {3},
  pages        = {138--142},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Nasal neutrophil activity and mucinous secretory responsiveness in COPD.},
  url          = {http://dx.doi.org/10.1046/j.1475-097X.2003.00484.x},
  volume       = {23},
  year         = {2003},
}