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Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans

Reinstrup, Peter LU ; Ryding, Erik LU ; Ohlsson, Tomas G LU ; Sandell, Anders LU ; Erlandsson, K; Ljunggren, Kaj LU ; Salford, Leif LU ; Strand, Sven-Erik LU and Uski, Tore LU (2008) In British Journal of Anaesthesia 100(1). p.66-71
Abstract
BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the... (More)
BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the distribution of the metabolism in the brain (P<0.0001 analysis of variance). Compared with inhalation of O2 30% in N2, N2O 50% inhalation increased the metabolism in the basal ganglia [14 (17)%, P<0.05] and thalamus [22 (23) %, P<0.05]. There was a prolonged metabolic effect of N2O inhalation seen on a succeeding PET scan with oxygen-enriched air (P<0.0001) performed 1 h after the N2O administration. CONCLUSIONS: Inhalation of N2O 50% did not change global CMR(glu), but the metabolism increased in central brain structures, an effect that was still present 1 h after discontinuation of N2O. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Anaesthesia
volume
100
issue
1
pages
66 - 71
publisher
Macmillan
external identifiers
  • wos:000251679600013
  • pmid:18037671
  • scopus:38449097835
ISSN
1471-6771
DOI
10.1093/bja/aem334
language
English
LU publication?
yes
id
038df61b-9660-412e-9818-65c8fc1d23a4 (old id 1139643)
date added to LUP
2008-08-04 15:03:10
date last changed
2017-01-01 04:59:30
@article{038df61b-9660-412e-9818-65c8fc1d23a4,
  abstract     = {BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the distribution of the metabolism in the brain (P&lt;0.0001 analysis of variance). Compared with inhalation of O2 30% in N2, N2O 50% inhalation increased the metabolism in the basal ganglia [14 (17)%, P&lt;0.05] and thalamus [22 (23) %, P&lt;0.05]. There was a prolonged metabolic effect of N2O inhalation seen on a succeeding PET scan with oxygen-enriched air (P&lt;0.0001) performed 1 h after the N2O administration. CONCLUSIONS: Inhalation of N2O 50% did not change global CMR(glu), but the metabolism increased in central brain structures, an effect that was still present 1 h after discontinuation of N2O.},
  author       = {Reinstrup, Peter and Ryding, Erik and Ohlsson, Tomas G and Sandell, Anders and Erlandsson, K and Ljunggren, Kaj and Salford, Leif and Strand, Sven-Erik and Uski, Tore},
  issn         = {1471-6771},
  language     = {eng},
  number       = {1},
  pages        = {66--71},
  publisher    = {Macmillan},
  series       = {British Journal of Anaesthesia},
  title        = {Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans},
  url          = {http://dx.doi.org/10.1093/bja/aem334},
  volume       = {100},
  year         = {2008},
}