Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans
(2008) In British Journal of Anaesthesia 100(1). p.66-71- Abstract
- BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the... (More)
- BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the distribution of the metabolism in the brain (P<0.0001 analysis of variance). Compared with inhalation of O2 30% in N2, N2O 50% inhalation increased the metabolism in the basal ganglia [14 (17)%, P<0.05] and thalamus [22 (23) %, P<0.05]. There was a prolonged metabolic effect of N2O inhalation seen on a succeeding PET scan with oxygen-enriched air (P<0.0001) performed 1 h after the N2O administration. CONCLUSIONS: Inhalation of N2O 50% did not change global CMR(glu), but the metabolism increased in central brain structures, an effect that was still present 1 h after discontinuation of N2O. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1139643
- author
- Reinstrup, Peter LU ; Ryding, Erik LU ; Ohlsson, Tomas G LU ; Sandell, Anders LU ; Erlandsson, K ; Ljunggren, Kaj LU ; Salford, Leif LU ; Strand, Sven-Erik LU and Uski, Tore LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Anaesthesia
- volume
- 100
- issue
- 1
- pages
- 66 - 71
- publisher
- Elsevier
- external identifiers
-
- wos:000251679600013
- pmid:18037671
- scopus:38449097835
- ISSN
- 1471-6771
- DOI
- 10.1093/bja/aem334
- language
- English
- LU publication?
- yes
- id
- 038df61b-9660-412e-9818-65c8fc1d23a4 (old id 1139643)
- date added to LUP
- 2016-04-01 12:16:02
- date last changed
- 2022-01-27 01:17:25
@article{038df61b-9660-412e-9818-65c8fc1d23a4, abstract = {{BACKGROUND: Recent studies in man have shown that cerebral blood flow increases during inhalation of nitrous oxide (N2O), a finding which is believed to be a result of an increased cerebral metabolic rate (CMR). However, this has not previously been evaluated in man. METHODS: Regional CMR(glu) (rCMR(glu)) was measured three dimensionally with positron emission tomography (PET) after injection of 2-(18F)fluoro-2-deoxy-D-glucose in 10 spontaneously breathing men (mean age 31 yr) inhaling either N2O 50% in O2 30% or O2 30% in N2. RESULTS: Global CMR(glu) in young men was 27 (3) micromol 100 g(-1) min(-1) [mean (SD)]. Inhalation of N2O 50% did not change global CMR(glu) [30 (5) micromol 100 g(-1) min(-1)] significantly, but it changed the distribution of the metabolism in the brain (P<0.0001 analysis of variance). Compared with inhalation of O2 30% in N2, N2O 50% inhalation increased the metabolism in the basal ganglia [14 (17)%, P<0.05] and thalamus [22 (23) %, P<0.05]. There was a prolonged metabolic effect of N2O inhalation seen on a succeeding PET scan with oxygen-enriched air (P<0.0001) performed 1 h after the N2O administration. CONCLUSIONS: Inhalation of N2O 50% did not change global CMR(glu), but the metabolism increased in central brain structures, an effect that was still present 1 h after discontinuation of N2O.}}, author = {{Reinstrup, Peter and Ryding, Erik and Ohlsson, Tomas G and Sandell, Anders and Erlandsson, K and Ljunggren, Kaj and Salford, Leif and Strand, Sven-Erik and Uski, Tore}}, issn = {{1471-6771}}, language = {{eng}}, number = {{1}}, pages = {{66--71}}, publisher = {{Elsevier}}, series = {{British Journal of Anaesthesia}}, title = {{Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans}}, url = {{http://dx.doi.org/10.1093/bja/aem334}}, doi = {{10.1093/bja/aem334}}, volume = {{100}}, year = {{2008}}, }