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The COMT val158met polymorphism is associated with prevalent fractures in Swedish men

Eriksson, Anna L; Mellstrom, Dan; Lorentzon, Mattias; Orwoll, Eric S; Redlund-Johnell, Inga LU ; Grundberg, Elin; Holmberg, Anna H LU ; Ljunggren, Osten; Karlsson, Magnus LU and Ohlsson, Claes (2008) In Bone 42(1). p.107-112
Abstract
INTRODUCTION: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. METHODS: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. RESULTS: Total number... (More)
INTRODUCTION: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. METHODS: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. RESULTS: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of >/=1 fracture was 37.2% in COMT(LL), 35.7% in COMT(HL) and 30.4% in COMT(HH) (p<0.05). Early fractures (</=50 years of age) were less common in COMT(HH) than in the combined COMT(LL+HL) genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (>50 years of age). The OR for fracture of the non-weight bearing skeleton in COMT(HH) compared with COMT(LL+HL) was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. CONCLUSIONS: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (</=50 years of age). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bone
volume
42
issue
1
pages
107 - 112
publisher
Elsevier
external identifiers
  • pmid:17962094
  • wos:000252518100014
  • scopus:37449009741
ISSN
1873-2763
DOI
10.1016/j.bone.2007.08.045
language
English
LU publication?
yes
id
6aec2ce0-ec88-4111-86d1-5ffebe95628f (old id 1139655)
date added to LUP
2008-08-05 13:29:25
date last changed
2017-06-11 04:20:05
@article{6aec2ce0-ec88-4111-86d1-5ffebe95628f,
  abstract     = {INTRODUCTION: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men. METHODS: Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2822 individuals. RESULTS: Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of &gt;/=1 fracture was 37.2% in COMT(LL), 35.7% in COMT(HL) and 30.4% in COMT(HH) (p&lt;0.05). Early fractures (&lt;/=50 years of age) were less common in COMT(HH) than in the combined COMT(LL+HL) genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (&gt;50 years of age). The OR for fracture of the non-weight bearing skeleton in COMT(HH) compared with COMT(LL+HL) was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men. CONCLUSIONS: The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (&lt;/=50 years of age).},
  author       = {Eriksson, Anna L and Mellstrom, Dan and Lorentzon, Mattias and Orwoll, Eric S and Redlund-Johnell, Inga and Grundberg, Elin and Holmberg, Anna H and Ljunggren, Osten and Karlsson, Magnus and Ohlsson, Claes},
  issn         = {1873-2763},
  language     = {eng},
  number       = {1},
  pages        = {107--112},
  publisher    = {Elsevier},
  series       = {Bone},
  title        = {The COMT val158met polymorphism is associated with prevalent fractures in Swedish men},
  url          = {http://dx.doi.org/10.1016/j.bone.2007.08.045},
  volume       = {42},
  year         = {2008},
}