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Hypoxia and breast cancer: prognostic and therapeutic implications

Lundgren, Katja LU ; Wigerup, Caroline LU and Landberg, Göran LU (2007) In Cellular and Molecular Life Sciences 64(24). p.3233-3247
Abstract
Hypoxia affects many important processes in tumour progression and is a key feature in the tumour microenvironment that needs to be taken into account when evaluating prognostics and therapeutic options for cancer patients. Hypoxia-regulating proteins, i.e. hypoxia inducible factors (HIFs), and associated gene products have been linked to certain tumour behaviours and might be useful as prognostic and predictive markers. Recently, hypoxia-driven gene products have been launched as novel cancer treatment targets with the potential to increase tumour-specific effects. Breast cancer consists of a multitude of different diseases with certain common characteristics, but also clearly disparate behaviours and genetic alterations. In this review... (More)
Hypoxia affects many important processes in tumour progression and is a key feature in the tumour microenvironment that needs to be taken into account when evaluating prognostics and therapeutic options for cancer patients. Hypoxia-regulating proteins, i.e. hypoxia inducible factors (HIFs), and associated gene products have been linked to certain tumour behaviours and might be useful as prognostic and predictive markers. Recently, hypoxia-driven gene products have been launched as novel cancer treatment targets with the potential to increase tumour-specific effects. Breast cancer consists of a multitude of different diseases with certain common characteristics, but also clearly disparate behaviours and genetic alterations. In this review we will summarise the role of hypoxia in breast cancer and specifically outline the importance of hypoxia and HIF-1alpha regarding prognostic and treatment-specific implications. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hypoxia, HIF-1α, prognosis, treatment, Breast cancer
in
Cellular and Molecular Life Sciences
volume
64
issue
24
pages
3233 - 3247
publisher
Birkhaüser
external identifiers
  • pmid:17957335
  • wos:000252219000008
  • scopus:39749110780
ISSN
1420-9071
DOI
10.1007/s00018-007-7390-6
language
English
LU publication?
yes
id
16a63465-7909-46f7-8c69-cc490722d147 (old id 1139761)
date added to LUP
2008-08-20 15:54:23
date last changed
2017-11-05 04:37:27
@article{16a63465-7909-46f7-8c69-cc490722d147,
  abstract     = {Hypoxia affects many important processes in tumour progression and is a key feature in the tumour microenvironment that needs to be taken into account when evaluating prognostics and therapeutic options for cancer patients. Hypoxia-regulating proteins, i.e. hypoxia inducible factors (HIFs), and associated gene products have been linked to certain tumour behaviours and might be useful as prognostic and predictive markers. Recently, hypoxia-driven gene products have been launched as novel cancer treatment targets with the potential to increase tumour-specific effects. Breast cancer consists of a multitude of different diseases with certain common characteristics, but also clearly disparate behaviours and genetic alterations. In this review we will summarise the role of hypoxia in breast cancer and specifically outline the importance of hypoxia and HIF-1alpha regarding prognostic and treatment-specific implications.},
  author       = {Lundgren, Katja and Wigerup, Caroline and Landberg, Göran},
  issn         = {1420-9071},
  keyword      = {hypoxia,HIF-1α,prognosis,treatment,Breast cancer},
  language     = {eng},
  number       = {24},
  pages        = {3233--3247},
  publisher    = {Birkhaüser},
  series       = {Cellular and Molecular Life Sciences},
  title        = {Hypoxia and breast cancer: prognostic and therapeutic implications},
  url          = {http://dx.doi.org/10.1007/s00018-007-7390-6},
  volume       = {64},
  year         = {2007},
}